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Medecine sciences : M/S
Apr, 2023;39 (4): 344-350.

[The circular life of viruses].

Alexis Serge Chasseur, Benoît Muylkens, Damien Coupeau
Author Information
  1. Alexis Serge Chasseur: Virologie moléculaire, Namur Research Institute for Life Sciences (Narilis), Unité de recherche vétérinaire intégrée, université de Namur (UNamur), Namur, Belgique. ORCID
  2. Benoît Muylkens: Virologie moléculaire, Namur Research Institute for Life Sciences (Narilis), Unité de recherche vétérinaire intégrée, université de Namur (UNamur), Namur, Belgique.
  3. Damien Coupeau: Virologie moléculaire, Namur Research Institute for Life Sciences (Narilis), Unité de recherche vétérinaire intégrée, université de Namur (UNamur), Namur, Belgique. ORCID
PMID: 37094267 DOI: 10.1051/medsci/2023051

Abstract

Circular RNAs (circRNA), as ancient as the first viruses, take an important part in the host-pathogen relationship. After the first description of dysregulated cellular circRNAs upon viral infection, numerous circRNAs of viral origin were identified and characterized. They are impacting both viral and cellular cycles and are associated with virus-induced oncogenesis, immune system regulation and cell differentiation. While the naïve reader might get swamped by discovering this new field of RNA biology, it seems that these RNA rings are actually full of surprises and wonders at both a functional and a biogenesis level.

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Grants

  1. 40009229/FRIA/FNRS

MeSH Term

Humans
RNA, Circular
RNA
Virus Diseases
Genes, Viral
Viruses

Chemicals

RNA, Circular
RNA
English Abstract Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0viralfirstcellularcircRNAsRNACircularRNAscircRNAancientvirusestakeimportantparthost-pathogenrelationshipdescriptiondysregulateduponinfectionnumerousoriginidentifiedcharacterizedimpactingcyclesassociatedvirus-inducedoncogenesisimmunesystemregulationcelldifferentiationnaïvereadermightgetswampeddiscoveringnewfieldbiologyseemsringsactuallyfullsurpriseswondersfunctionalbiogenesislevel[Thecircularlifeviruses]

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