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Current topics in microbiology and immunology
2023;440 147-164.

Lassa Virus Structural Biology and Replication.

Robert F Garry
Author Information
  1. Robert F Garry: School of Medicine, Department of Microbiology and Immunology, Tulane University, New Orleans, LA, 70112, USA. rfgarry@tulane.edu.
PMID: 37100973 DOI: 10.1007/82_2023_262

Abstract

Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic fever that is endemic in West Africa. LASV virions are enveloped and contain two single-stranded RNA genome segments. Both segments are ambisense and encode two proteins. The nucleoprotein associates with viral RNAs forming ribonucleoprotein complexes. The glycoprotein complex mediates viral attachment and entry. The Zinc protein serves as the matrix protein. Large is a polymerase that catalyzes viral RNA transcription and replication. LASV virion entry occurs via a clathrin-independent endocytic pathway usually involving alpha-dystroglycan and lysosomal associated membrane protein 1 as surface and intracellular receptors, respectively. Advances in understanding LASV structural biology and replication have facilitated development of promising vaccine and drug candidates.

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MeSH Term

Humans
Lassa virus
Lassa Fever
Biology
Africa, Western
Journal Article
Article has an altmetric score of 2

Word Cloud

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