Efficacy of Platelet-Rich Plasma Therapy in Oral Lichen Planus: A Systematic Review.
Shyamkumar Sriram, Shamimul Hasan, Abdullah Alqarni, Tanveer Alam, Sultan Mohammed Kaleem, Shahid Aziz, Humayoun Khan Durrani, Muhammed Ajmal, Ali Azhar Dawasaz, Shazina Saeed
Author Information
Shyamkumar Sriram: Department of Social and Public Health, Ohio University, Athens, OH 45701, USA.
Shamimul Hasan: Department of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025, India. ORCID
Abdullah Alqarni: Department of Diagnostic Dental Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Tanveer Alam: Department of Diagnostic Dental Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Sultan Mohammed Kaleem: Department of Diagnostic Dental Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Shahid Aziz: Department of Medicine, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia. ORCID
Humayoun Khan Durrani: Department of Medicine, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia.
Muhammed Ajmal: Department of Diagnostic Dental Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia.
Ali Azhar Dawasaz: Department of Diagnostic Dental Sciences and Oral Biology, College of Dentistry, King Khalid University, Abha 62529, Saudi Arabia. ORCID
Shazina Saeed: Amity Institute of Public Health & Hospital Administration, Amity University, Noida 201303, India.
: Oral lichen planus (OLP) is an autoimmune, mucocutaneous, oral potentially malignant disorder (OPMD), which characteristically manifests with chronic, recalcitrant lesions, with frequent flare-ups and remissions. The precise etiopathogenesis of OLP is still debatable, although it is believed to be a T-cell-mediated disorder of an unidentified antigen. Despite the availability of various treatments, no cure for OLP exists due to its recalcitrant nature and idiopathic etiology. Platelet-rich plasma (PRP) has antioxidant, anti-inflammatory, and immunomodulatory properties, in addition to its regulatory action on keratinocyte differentiation and proliferation. These salient properties substantiate the possible role of PRP in the treatment of OLP. Our systematic review focuses on assessing the therapeutic potential of PRP as a treatment modality in OLP. : We conducted a detailed literature search for studies assessing PRP as a therapeutic regimen in OLP, using the Google Scholar and PubMed/MEDLINE search engines. The search was limited to studies published from January 2000 to January 2023 and included a combination of Medical Subject Heading (MeSH) terms. ROBVIS analysis was carried out for the assessment of publication bias. Descriptive statistics were performed using Microsoft Excel. : This systematic review included five articles that met the inclusion criteria. Most of the included studies demonstrated that PRP treatment considerably ameliorated both objective and subjective symptoms in OLP subjects, with comparable efficacy to the standard corticosteroid treatment. Further, PRP therapy offers the added benefit of minimal adverse effects and recurrences. : This systematic review suggests that PRP has significant therapeutic potential for treating OLP. However, further research with larger sample sizes is imperative to corroborate these findings.
