Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy.
Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina, William C Cho
Author Information
Javad Sharifi-Rad: Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. javad.sharifirad@gmail.com.
Veronique Seidel: Natural Products Research Laboratory, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK.
Michalak Izabela: Department of Advanced Material Technologies, Faculty of Chemistry, Wroclaw University of Science and Technology, Smoluchowskiego 25, 50-372, Wroclaw, Poland.
Margalida Monserrat-Mequida: Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122, Palma, Spain.
Antoni Sureda: Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122, Palma, Spain.
Valeska Ormazabal: Department of Pharmacology, Faculty of Biological Sciences, University of Concepción, Concepción, Chile.
Felipe A Zuniga: Department of Clinical Biochemistry and Immunology, Faculty of Pharmacy, University of Concepción, Concepción, Chile.
Shivaprasad Shetty Mangalpady: Department of Chemistry, NMAM Institute of Technology, Nitte, Karnataka, 574110, India.
Raffaele Pezzani: Phytotherapy Lab, Endocrinology Unit, Department of Medicine (DIMED), University of Padova, Via Ospedale 105, 35128, Padova, Italy.
Alibek Ydyrys: Biomedical Research Centre, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, 050040, Almaty, Kazakhstan.
Gulmira Tussupbekova: Department of Biophysics, Biomedicine and Neuroscience, Al-Farabi Kazakh National University, Al-Farabi Ave. 71, 050040, Almaty, Kazakhstan.
Miquel Martorell: Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, Chile. mmartorell@udec.cl.
Daniela Calina: Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. calinadaniela@gmail.com.
William C Cho: Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong. chocs@ha.org.hk.
Cancer is a leading cause of death worldwide and involves an oxidative stress mechanism. The transcription factor Nrf2 has a crucial role in cytoprotective response against oxidative stress, including cancer growth and progression and therapy resistance. For this reason, inhibitors of Nrf2 are new targets to be studied. Traditional plant-based remedies rich in phytochemicals have been used against human cancers and phenolic compounds are known for their chemopreventive properties. This comprehensive review offers an updated review of the role of phenolic compounds as anticancer agents due to their action on Nrf2 inhibition. In addition, the role of naturally-occurring bioactive anticancer agents are covered in the clinical applications of polyphenols as Nrf2 inhibitors. Video Abstract.
