Spontaneously occurring tumors in different wild-derived strains of hydra.
Justine Boutry, Marie Buysse, Sophie Tissot, Chantal Cazevielle, Rodrigo Hamede, Antoine M Dujon, Beata Ujvari, Mathieu Giraudeau, Alexander Klimovich, Frédéric Thomas, Jácint Tökölyi
Author Information
Justine Boutry: CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France. justine.boutry@gmail.com.
Marie Buysse: MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France.
Sophie Tissot: CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France.
Chantal Cazevielle: Institut des Neurosciences de Montpellier: Electronic Microscopy Facilities, INSERM U 1298, Université Montpellier, Montpellier, France.
Rodrigo Hamede: CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France.
Antoine M Dujon: Centre for Integrative Ecology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia.
Beata Ujvari: CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France.
Mathieu Giraudeau: Littoral Environnement et Sociétés (LIENSs), UMR 7266 CNRS-La Rochelle Université, 223 Rue Olympe de Gouges, 17000, La Rochelle, France.
Alexander Klimovich: Zoological Institute, Christian-Albrechts University, 24118, Kiel, Germany.
Frédéric Thomas: CREEC/CANECEV (CREES), MIVEGEC, Unité Mixte de Recherches, IRD 224-CNRS 5290, Université de Montpellier, Montpellier, France.
Jácint Tökölyi: MTA-DE "Momentum" Ecology, Evolution and Developmental Biology Research Group, Department of Evolutionary Zoology, University of Debrecen, Debrecen, 4032, Hungary. jtokolyi@mailbox.unideb.hu.
Hydras are freshwater cnidarians widely used as a biological model to study different questions such as senescence or phenotypic plasticity but also tumoral development. The spontaneous tumors found in these organisms have been so far described in two female lab strains domesticated years ago (Hydra oligactis and Pelmatohydra robusta) and the extent to which these tumors can be representative of tumors within the diversity of wild hydras is completely unknown. In this study, we examined individuals isolated from recently sampled wild strains of different sex and geographical origin, which have developed outgrowths looking like tumors. These tumefactions have common features with the tumors previously described in lab strains: are composed of an accumulation of abnormal cells, resulting in a similar enlargement of the tissue layers. However, we also found diversity within these new types of tumors. Indeed, not only females, but also males seem prone to form these tumors. Finally, the microbiota associated to these tumors is different from the one involved in the previous lineages exhibiting tumors. We found that tumorous individuals hosted yet undescribed Chlamydiales vacuoles. This study brings new insights into the understanding of tumor susceptibility and diversity in brown hydras from different origins.
