The VGNC: expanding standardized vertebrate gene nomenclature.

Tamsin E M Jones, Bethan Yates, Bryony Braschi, Kristian Gray, Susan Tweedie, Ruth L Seal, Elspeth A Bruford
Author Information
  1. Tamsin E M Jones: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK. tjones@ebi.ac.uk. ORCID
  2. Bethan Yates: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
  3. Bryony Braschi: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
  4. Kristian Gray: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
  5. Susan Tweedie: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
  6. Ruth L Seal: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.
  7. Elspeth A Bruford: HUGO Gene Nomenclature Committee, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, CB10 1SD, Cambridgeshire, UK.

Abstract

The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 as a sister project to the HUGO Gene Nomenclature Committee, to approve gene nomenclature in vertebrate species without an existing dedicated nomenclature committee. The VGNC aims to harmonize gene nomenclature across selected vertebrate species in line with human gene nomenclature, with orthologs assigned the same nomenclature where possible. This article presents an overview of the VGNC project and discussion of key findings resulting from this work to date. VGNC-approved nomenclature is accessible at https://vertebrate.genenames.org and is additionally displayed by the NCBI, Ensembl, and UniProt databases.

Keywords

References

  1. Nucleic Acids Res. 2019 Jan 8;47(D1):D155-D162 [PMID: 30423142]
  2. Mol Phylogenet Evol. 2017 Nov;116:78-86 [PMID: 28851538]
  3. BMC Evol Biol. 2020 Apr 15;20(1):42 [PMID: 32295537]
  4. Hum Genomics. 2010 Feb;4(3):213-7 [PMID: 20368143]
  5. Nature. 2023 Feb;614(7948):E31-E32 [PMID: 36792746]
  6. Nature. 2021 Apr;592(7856):737-746 [PMID: 33911273]
  7. Proc Biol Sci. 2018 Sep 12;285(1886): [PMID: 30209232]
  8. BMC Genomics. 2009 Jul 14;10 Suppl 2:S5 [PMID: 19607656]
  9. Nucleic Acids Res. 2020 Jan 8;48(D1):D776-D782 [PMID: 31733057]
  10. Nucleic Acids Res. 2021 Jan 8;49(D1):D939-D946 [PMID: 33152070]
  11. PLoS One. 2017 Aug 28;12(8):e0180359 [PMID: 28846680]
  12. Brief Bioinform. 2021 Nov 5;22(6): [PMID: 33959747]
  13. Genes Immun. 2022 Sep;23(6):175-182 [PMID: 36151402]
  14. Nucleic Acids Res. 2019 Jan 8;47(D1):D801-D806 [PMID: 30407599]
  15. Genetics. 2022 Apr 4;220(4): [PMID: 35166825]
  16. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11736-41 [PMID: 12192086]
  17. Immunogenetics. 2020 Feb;72(1-2):49-55 [PMID: 31641782]
  18. Epigenetics Chromatin. 2022 Oct 1;15(1):34 [PMID: 36180920]
  19. Nucleic Acids Res. 2017 Jan 4;45(D1):D619-D625 [PMID: 27799471]
  20. Nucleic Acids Res. 2022 Jan 7;50(D1):D20-D26 [PMID: 34850941]
  21. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16036-16045 [PMID: 31332008]
  22. Nucleic Acids Res. 2020 Jan 8;48(D1):D731-D742 [PMID: 31713623]
  23. Nucleic Acids Res. 2021 Jan 8;49(D1):D373-D379 [PMID: 33174605]
  24. Mamm Genome. 2005 Nov;16(11):827-8 [PMID: 16284797]
  25. Nucleic Acids Res. 2021 Jan 8;49(D1):D480-D489 [PMID: 33237286]
  26. Nat Genet. 2020 Aug;52(8):754-758 [PMID: 32747822]
  27. Nucleic Acids Res. 2022 Jan 7;50(D1):D988-D995 [PMID: 34791404]
  28. Nucleic Acids Res. 2021 Jan 8;49(D1):D394-D403 [PMID: 33290554]

Grants

  1. U24 HG003345/NHGRI NIH HHS
  2. 208349/Z/17/Z/Wellcome Trust

MeSH Term

Animals
Humans
Databases, Genetic
Vertebrates

Word Cloud

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