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Frontiers in oncology
2023;13 1170122.

Chitinase-like proteins promoting tumorigenesis through disruption of cell polarity enlarged endosomal vesicles.

Dilan Khalili, Martin Kunc, Sarah Herbrich, Anna M Müller, Ulrich Theopold
Author Information
  1. Dilan Khalili: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  2. Martin Kunc: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  3. Sarah Herbrich: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  4. Anna M Müller: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
  5. Ulrich Theopold: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
PMID: 37188187 DOI: 10.3389/fonc.2023.1170122

Abstract

Introduction: Chitinase-like proteins (CLPs) are associated with tissue-remodeling and inflammation but also with several disorders, including fibrosis, atherosclerosis, allergies, and cancer. However, CLP's role in tumors is far from clear.
Methods: Here, we utilize and molecular genetics to investigate the function of CLPs (imaginal disc growth factors; Idgf's) in dysplastic salivary glands.
Results and discussion: We find one of the Idgf's members, , is transcriptionally induced in a JNK-dependent manner via a positive feedback loop mediated by reactive oxygen species (ROS). Moreover, accumulates in enlarged endosomal vesicles (EnVs) that promote tumor progression by disrupting cytoskeletal organization. The process is mediated the downstream component, aSpectrin, which localizes to the EnVs. Our data provide new insight into CLP function in tumors and identifies specific targets for tumor control.

Keywords

Drosophila chitinase endosomal vesicles immunity insect immunity salivary glands tumor

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Journal Article
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