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Alzheimer's & dementia : the journal of the Alzheimer's Association
09, 2023;19 (9): 4046-4060.

Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS): Study design and harmonization.

Lucia Crivelli, Ismael Luis Calandri, Claudia Kimie Suemoto, Rosa María Salinas, Lina Marcela Velilla, Mônica Sanches Yassuda, Paulo Caramelli, Francisco Lopera, Ricardo Nitrini, Gustavo Emilio Sevlever, Ana Luisa Sosa, Daisy Acosta, Ana María Charamelo Baietti, María Isabel Cusicanqui, Nilton Custodio, Sergio Dansilio De Simone, Carolina Delgado Derio, Lissette Duque-Peñailillo, Juan Carlos Duran, Ivonne Z Jiménez-Velázquez, Jorge Mario Leon-Salas, Yanina Bergamo, María Florencia Clarens, Andrés Damian, Ignacio Demey, María Belén Helou, Carlos Márquez, María Eugenia Martin, Maria da Graça Morais Martin, Diego Querze, Ezequiel Ignacio Surace, Sabrina Acosta-Egea, Esteban Aguirre-Salvador, Leonardo Cruz de Souza, Gustavo Henrique da Cunha Peixoto Cançado, Sonia Maria Dozzi Brucki, Clarisse Vasconcelos Friedlaender, Karina Braga Gomes, Myriam Gutierrez, Carlos Laforcada Ríos, Joyce Graciela Martinez Galindo, Rosa Montesinos, Alberto Nuñez-Herrera, Sebastián Ospina-Henao, Guillermina Rodríguez, Victoria Ruiz Masson, Mónica Sánchez, Christian E Schenk, Ligia Soto, Maira Tonidandel Barbosa, Jéssica Abdo Gonçalves Tosatti, Yosselin Vicuña, Mark Espeland, Krister Hakansson, Miia Kivipelto, Laura Baker, Heather Snyder, María Carrillo, Ricardo Francisco Allegri
Author Information
  1. Lucia Crivelli: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  2. Ismael Luis Calandri: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  3. Claudia Kimie Suemoto: Division of Geriatrics, University of São Paulo Medical School, São Paulo, Brazil.
  4. Rosa María Salinas: Laboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
  5. Lina Marcela Velilla: Neuroscience Group of Antioquia Medical School, Antioquia University, Medellín, Colombia.
  6. Mônica Sanches Yassuda: Cognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
  7. Paulo Caramelli: Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  8. Francisco Lopera: Neuroscience Group of Antioquia Medical School, Antioquia University, Medellín, Colombia.
  9. Ricardo Nitrini: Cognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
  10. Gustavo Emilio Sevlever: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  11. Ana Luisa Sosa: Laboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
  12. Daisy Acosta: Internal Medicine Department, Universidad Nacional Pedro Henriquez Urena (UNPHU), Santo Domingo, Dominican Republic.
  13. Ana María Charamelo Baietti: Clínica de la Memoria-Hospital Británico, Montevideo, Uruguay.
  14. María Isabel Cusicanqui: Centro Neurológico Mente Activa, La Paz, Bolivia.
  15. Nilton Custodio: Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
  16. Sergio Dansilio De Simone: Departamento de Neuropsicología, Facultad de Medicina-Hospital de Clínicas, Universidad de la República, Montevideo, Uruguay.
  17. Carolina Delgado Derio: Unidad de Cerebro Saludable, Departamento de Neurología y Neurocirugía, Hospital Clínico Universidad de Chile, Santiago de Chile, Chile.
  18. Lissette Duque-Peñailillo: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  19. Juan Carlos Duran: Centro Neurológico Mente Activa, La Paz, Bolivia.
  20. Ivonne Z Jiménez-Velázquez: Centro de Investigación en Geriatría, Departamento de Medicina Interna, Recinto de Ciencias Médicas, Universidad de Puerto Rico, San Juan, Puerto Rico.
  21. Jorge Mario Leon-Salas: Departamento de Investigación Clínica, Life Science Research Institute, Hospital Clínica Bíblica, San José, Costa Rica.
  22. Yanina Bergamo: Department of Diagnostic Imaging, Fleni, Buenos Aires, Argentina.
  23. María Florencia Clarens: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  24. Andrés Damian: CUDIM Centro Uruguayo de Imagenología Molecular, Montevideo, Uruguay.
  25. Ignacio Demey: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  26. María Belén Helou: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  27. Carlos Márquez: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago de Chile, Chile.
  28. María Eugenia Martin: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
  29. Maria da Graça Morais Martin: Department of Radiology HCFMUSP, University of São Paulo School of Medicine, São Paulo, Brazil.
  30. Diego Querze: Department of Neurology, Fleni, Buenos Aires, Argentina.
  31. Ezequiel Ignacio Surace: Department of Molecular Biology and Bioinformatics, Fleni, Buenos Aires, Argentina.
  32. Sabrina Acosta-Egea: Departamento de Investigación Clínica, Life Science Research Institute, Hospital Clínica Bíblica, San José, Costa Rica.
  33. Esteban Aguirre-Salvador: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  34. Leonardo Cruz de Souza: Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  35. Gustavo Henrique da Cunha Peixoto Cançado: Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  36. Sonia Maria Dozzi Brucki: Cognitive and Behavioral Neurology Unit, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brazil.
  37. Clarisse Vasconcelos Friedlaender: Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  38. Karina Braga Gomes: Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  39. Myriam Gutierrez: Unidad de Cerebro Saludable, Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile.
  40. Carlos Laforcada Ríos: Centro Neurológico Mente Activa, La Paz, Bolivia.
  41. Joyce Graciela Martinez Galindo: Laboratorio de Demencias del Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Ciudad de México, México.
  42. Rosa Montesinos: Unidad de Diagnóstico de Deterioro Cognitivo y Prevención de Demencia, Instituto Peruano de Neurociencias, Lima, Perú.
  43. Alberto Nuñez-Herrera: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  44. Sebastián Ospina-Henao: Facultad de Medicina, Universidad de Ciencias Médicas, Instituto de Investigación en Ciencias Médicas, San José, Costa Rica.
  45. Guillermina Rodríguez: Department of Demography and Biostatistics, Ministry of Public Health, Santo Domingo, Dominican Republic.
  46. Victoria Ruiz Masson: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  47. Mónica Sánchez: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  48. Christian E Schenk: Neurology Division, Medical Sciences Campus, University of Puerto Rico, San Juan, Puerto Rico.
  49. Ligia Soto: Cognitive Disorders Unit-Neuromedicenter, Quito, Ecuador.
  50. Maira Tonidandel Barbosa: Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  51. Jéssica Abdo Gonçalves Tosatti: Behavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
  52. Yosselin Vicuña: Inbiomed (Instituto de Investigación en Biomedicina), Universidad Central del Ecuador, Quito, Ecuador.
  53. Mark Espeland: Departments of Internal Medicine and Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  54. Krister Hakansson: Division of Clinical Geriatrics, Karolinska Institutet, Stockholm, Sweden.
  55. Miia Kivipelto: Division of Clinical Geriatrics, Centre for Alzheimer Research, Karolinska Institutet and Theme Inflammation and Aging, Karolinska University Hospital, Stockholm, Sweden.
  56. Laura Baker: Departments of Internal Medicine, Neurology, and Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  57. Heather Snyder: Alzheimer's Association, Chicago, Illinois, USA.
  58. María Carrillo: Alzheimer's Association, Chicago, Illinois, USA.
  59. Ricardo Francisco Allegri: Department of Cognitive Neurology, Fleni, Buenos Aires, Argentina.
PMID: 37204054 DOI: 10.1002/alz.13101

Abstract

INTRODUCTION: Latin American Initiative for Lifestyle Intervention to Prevent Cognitive Decline (LatAm-FINGERS) is the first non-pharmacological multicenter randomized clinical trial (RCT) to prevent cognitive impairment in Latin America (LA). Our aim is to present the study design and discuss the strategies used for multicultural harmonization.
METHODS: This 1-year RCT (working on a 1-year extension) investigates the feasibility of a multi-domain lifestyle intervention in LA and the efficacy of the intervention, primarily on cognitive function. An external harmonization process was carried out to follow the FINGER model, and an internal harmonization was performed to ensure this study was feasible and comparable across the 12 participating LA countries.
RESULTS: Currently, 1549 participants have been screened, and 815 randomized. Participants are ethnically diverse (56% are Nestizo) and have high cardiovascular risk (39% have metabolic syndrome).
DISCUSSION: LatAm-FINGERS overcame a significant challenge to combine the region's diversity into a multi-domain risk reduction intervention feasible across LA while preserving the original FINGER design.

Keywords

Alzheimer's disease World-Wide FINGERS cognitive impairment dementia lifestyle multidomain intervention prevention randomized controlled trial

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Grants

  1. P30 AG066546/NIA NIH HHS
  2. R13 AG066391/NIA NIH HHS

MeSH Term

Humans
Latin America
Cognitive Dysfunction
Life Style
Cognition
Research Design
Randomized Controlled Trial Multicenter Study Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural
Article has an altmetric score of 48

Word Cloud

Created with Highcharts 10.0.0LAharmonizationinterventionLatinLatAm-FINGERSrandomizedcognitivedesignAmericanInitiativeLifestyleInterventionPreventCognitiveDeclinetrialRCTimpairmentstudy1-yearmulti-domainlifestyleFINGERfeasibleacrossriskINTRODUCTION:firstnon-pharmacologicalmulticenterclinicalpreventAmericaaimpresentdiscussstrategiesusedmulticulturalMETHODS:workingextensioninvestigatesfeasibilityefficacyprimarilyfunctionexternalprocesscarriedfollowmodelinternalperformedensurecomparable12participatingcountriesRESULTS:Currently1549participantsscreened815Participantsethnicallydiverse56%Nestizohighcardiovascular39%metabolicsyndromeDISCUSSION:overcamesignificantchallengecombineregion'sdiversityreductionpreservingoriginal:StudyAlzheimer'sdiseaseWorld-WideFINGERSdementiamultidomainpreventioncontrolled

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