Self-Sorting in Diastereomeric Mixtures of Functionalized Dipeptides.
Qingwen Guan, Kate McAulay, Tian Xu, Sarah E Rogers, Charlotte Edwards-Gayle, Ralf Schweins, Honggang Cui, Annela M Seddon, Dave J Adams
Author Information
Qingwen Guan: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K. ORCID
Kate McAulay: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K.
Tian Xu: Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States. ORCID
Sarah E Rogers: ISIS Pulsed Neutron Source, Rutherford Appleton Laboratory, Didcot, OX11 0QX, U.K.
Charlotte Edwards-Gayle: Diamond Light Source, Harwell Science and Innovation Campus, Didcot OX11 0QX, U.K.
Ralf Schweins: Large Scale Structures Group, Institut Laue-Langevin, 71 Avenue des Martyrs, CS 20156, F-38042 Grenoble,CEDEX 9, France. ORCID
Honggang Cui: Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland 21218, United States. ORCID
Annela M Seddon: School of Physics, HH Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, U.K.
Dave J Adams: School of Chemistry, University of Glasgow, Glasgow G12 8QQ, U.K. ORCID
Self-sorting in functionalized dipeptide systems can be driven by the chirality of a single amino acid, both at a high pH in the micellar state and at a low pH in the gel state. The structures formed are affected to some degree by the relative concentrations of each component showing the complexity of such an approach. The structures underpinning the gel network are predefined by the micellar structures at a high pH. Here, we describe the systems prepared from two dipeptide-based gelators that differ only by the chirality of one of the amino acids. We provide firm evidence for self-sorting in the micellar and gel phases using small-angle neutron scattering and cryo-transmission electron microscopy (cryo-TEM), showing that complete self-sorting occurs across a range of relative concentrations.
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