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JPEN. Journal of parenteral and enteral nutrition
08, 2023;47 (6): 802-811.

Association between GLIM-defined malnutrition and hospitalizations in kidney transplant candidates: A post hoc analysis of a cohort study.

Vanesa Dávalos-Yerovi, Maria José Pérez-Sáez, Anna Faura-Vendrell, Maria Dolors Muns-Cornellas, Xavier Duran, Dolores Sánchez-Rodríguez, Julio Pascual, Ester Marco, FRAILMar Study Group
Author Information
  1. Vanesa Dávalos-Yerovi: Rehabilitation Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain. ORCID
  2. Maria José Pérez-Sáez: Department of Nephrology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
  3. Anna Faura-Vendrell: Department of Nephrology, Hospital del Mar, Parc de Salut Mar, Barcelona, Spain.
  4. Maria Dolors Muns-Cornellas: Endocrinology and Nutrition Department, Hospital del Mar, Barcelona, Spain.
  5. Xavier Duran: Methodology and Biostatistics Support Unit, Hospital del Mar Medical Research Institute, Barcelona, Spain.
  6. Dolores Sánchez-Rodríguez: Rehabilitation Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain. ORCID
  7. Julio Pascual: Rehabilitation Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain.
  8. Ester Marco: Rehabilitation Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain.
PMID: 37314213 DOI: 10.1002/jpen.2532

Abstract

BACKGROUND: Malnutrition is frequent in patients with chronic kidney disease (CKD) and has a negative impact on morbidity, mortality, and quality of life. The objective of this study was to assess the value of the Global Leadership Initiative for Malnutrition (GLIM) criteria to predict hospitalizations and mortality in candidates to kidney transplant during their first year on the waiting list.
METHODS: This was a post hoc analysis of 368 patients with advanced CKD. The main study variables were malnutrition, according to the GLIM criteria; number of hospital admissions during the first year on the waiting list; and mortality at the end of follow-up. Kaplan-Meier survival curves and binary logistic regression were performed, adjusting for age, frailty status, handgrip strength, and Charlson Index as potential confounders.
RESULTS: The prevalence of malnutrition was 32.6%. Malnutrition was associated with increased risk of hospitalizations during the first year on the waiting list (odds ratio [OR] = 3.33 [95% CI = 1.34-8.26]), which persisted after adjustment for age and frailty status (adjusted OR = 3.61 [95% CI = 1.38-10.7]), age and handgrip strength (adjusted OR = 3.39 [95% CI = 1.3-8.85]), and age and Charlson Index (adjusted OR = 3.25 [95% CI = 1.29-8.13]).
CONCLUSION: Malnutrition according to the GLIM criteria was highly prevalent in patients with CKD and was associated with a threefold increased risk of hospitalizations during the first year on the waiting list; these associations remained significant after adjusting for age, frailty status, handgrip strength, and comorbidities.

Keywords

GLIM advanced chronic kidney disease hospitalization malnutrition mortality

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MeSH Term

Humans
Cohort Studies
Frailty
Hand Strength
Kidney Transplantation
Leadership
Quality of Life
Hospitalization
Malnutrition
Renal Insufficiency, Chronic
Nutrition Assessment
Nutritional Status
Journal Article Research Support, Non-U.S. Gov't

Word Cloud

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