Fariha Ilyas: Department of Internal Medicine, ECU Health Medical Center, Brody School of Medicine, Greenville, North Carolina, USA. ORCID
Hassam Ali: Department of Internal Medicine, ECU Health Medical Center, Brody School of Medicine, Greenville, North Carolina, USA. ORCID
Pratik Patel: Department of Gastroenterology, Mather Hospital, Hofstra University Zucker School of Medicine, Port Jefferson, New York, USA. ORCID
Debargha Basuli: Department of Internal Medicine, ECU Health Medical Center, Brody School of Medicine, Greenville, North Carolina, USA. ORCID
Alexa Giammarino: Department of Internal Medicine, North Shore University Hospital, Zucker School of Medicine at Hofstra University, Manhasset, New York, USA. ORCID
Sanjaya K Satapathy: Department of Hepatology, North Shore University Hospital, Zucker School of Medicine at Hofstra University, Manhasset, New York, USA. ORCID
We examined trends in alcohol-associated liver disease (ALD)-related mortality in the United States from 1999 to 2022, focusing on sex, racial differences, and specific age groups. We analyzed age-adjusted mortality rates for ALD-related deaths using the CDC WONDER database and assessed differences between sex and racial groups. ALD-related mortality rates increased significantly between 1999 and 2022, with a more pronounced increase in females. White, Asian, Pacific Islander (AAPI), and American Indian or Alaska Native (AI/AN) groups showed significant uptrends in ALD-related mortality, while African Americans (AA) experienced a nonsignificant decline. Age-specific trends revealed substantial increases in crude mortality rates across various age groups, with the largest increase observed in the younger age groups of 25-34 years, with an average percent change of 11.12% from 2006 to 2022 (average annual percent change of 7.1% for the study period), and 35-44 years, which showed an average percent change of 17.2% from 2018 to 2022 (average annual percent change of 3.8% for the study period). This study reveals increased ALD-related mortality rates in the United States from 1999 to 2022, with disparities among sex, racial groups, and younger age groups. Continued monitoring and evidence-based interventions are needed to address the growing burden of ALD-related mortality, particularly in the younger population.
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