A pediatric case series of invasive pneumococcal disease caused by serotype-19A despite full dose vaccination.
Burcu Ceylan Cura Yayla, Tugba Bedir Demirdag, Emine Akkuzu, Nursel Kara, Hasan Tezer, Anıl Tapisiz
Author Information
Burcu Ceylan Cura Yayla: Department of Pediatric Infectious Diseases, University of Health Science Ankara Training and Research Hospital, Ankara, Turkey. ORCID
Tugba Bedir Demirdag: Department of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
Emine Akkuzu: Department of Pediatric Intensive Care Unit, Gazi University Faculty of Medicine, Ankara, Turkey.
Nursel Kara: Department of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
Hasan Tezer: Department of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
Anıl Tapisiz: Department of Pediatric Infectious Diseases, Gazi University Faculty of Medicine, Ankara, Turkey.
is the leading cause of community-acquired pneumonia and bacterial meningitis in children. Although pneumococcal conjugate vaccines (PCVs) are commonly available, invasive pneumococcal disease (IPD) still remains a life-threatening complication. Serotype 19A has high invasive potential and is capable of causing extensive and destructive lung disease. This strain has greater invasive potential, may have a growth advantage over other pneumococcal serotypes in normally sterile sites, and is often resistant to multiple antibiotics. Although being a component of PCV13 vaccine, serotype 19A may still be seen in fully vaccinated children and can cause invasive disease. Herein, we present four cases of IPD caused by serotype 19A who received the full regimen of PCV13 vaccination.
