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Integrative and comparative biology
Dec 29, 2023;63 (6): 1485-1508.

Methods and Measures for Investigating Microscale Motility.

Karen Grace Bondoc-Naumovitz, Hannah Laeverenz-Schlogelhofer, Rebecca N Poon, Alexander K Boggon, Samuel A Bentley, Dario Cortese, Kirsty Y Wan
Author Information
  1. Karen Grace Bondoc-Naumovitz: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK. ORCID
  2. Hannah Laeverenz-Schlogelhofer: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK. ORCID
  3. Rebecca N Poon: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK.
  4. Alexander K Boggon: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK. ORCID
  5. Samuel A Bentley: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK.
  6. Dario Cortese: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK.
  7. Kirsty Y Wan: Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, Exeter, UK. ORCID
PMID: 37336589 DOI: 10.1093/icb/icad075

Abstract

Motility is an essential factor for an organism's survival and diversification. With the advent of novel single-cell technologies, analytical frameworks, and theoretical methods, we can begin to probe the complex lives of microscopic motile organisms and answer the intertwining biological and physical questions of how these diverse lifeforms navigate their surroundings. Herein, we summarize the main mechanisms of microscale motility and give an overview of different experimental, analytical, and mathematical methods used to study them across different scales encompassing the molecular-, individual-, to population-level. We identify transferable techniques, pressing challenges, and future directions in the field. This review can serve as a starting point for researchers who are interested in exploring and quantifying the movements of organisms in the microscale world.

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Grants

  1. /European Research Council

MeSH Term

Animals
Movement
Single-Cell Analysis
Models, Theoretical
Cell Movement
Bacteria
Review Journal Article
Article has an altmetric score of 26

Word Cloud

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