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06 23, 2023;13 (1): 10214.

Resistance training rejuvenates aging skin by reducing circulating inflammatory factors and enhancing dermal extracellular matrices.

Shu Nishikori, Jun Yasuda, Kao Murata, Junya Takegaki, Yasuko Harada, Yuki Shirai, Satoshi Fujita
Author Information
  1. Shu Nishikori: Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Japan.
  2. Jun Yasuda: Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Japan.
  3. Kao Murata: Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Japan.
  4. Junya Takegaki: Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Japan.
  5. Yasuko Harada: Frontier Research Center, POLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama, Japan.
  6. Yuki Shirai: Frontier Research Center, POLA Chemical Industries, Inc., 560 Kashio-cho, Totsuka-ku, Yokohama, Japan.
  7. Satoshi Fujita: Faculty of Sport and Health Science, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Japan. safujita@fc.ritsumei.ac.jp.
PMID: 37353523 DOI: 10.1038/s41598-023-37207-9

Abstract

Aerobic training (AT) is suggested to be an effective anti-aging strategy for skin aging. However, the respective effects of resistance training (RT) have not been studied. Therefore, we compared the effects of AT and RT on skin aging in a 16-week intervention in 61 healthy sedentary middle-aged Japanese women. Data from 56 women were available for analysis. Both interventions significantly improved skin elasticity and upper dermal structure, and RT also improved dermal thickness. After the training intervention, expression of dermal extracellular matrix-related genes was increased in normal human primary dermal fibroblasts. AT and RT had different effects on circulating levels of factors, such as cytokines, hormones in serum, and metabolites, and RT increased dermal biglycan (BGN). To our knowledge, this is the first report to show different effects of AT and RT on skin aging and identify the key factors involved in RT-induced skin rejuvenation.

Associated Data

figshare | 10.6084/m9.figshare.22216876

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MeSH Term

Middle Aged
Humans
Female
Skin Aging
Resistance Training
Skin
Extracellular Matrix
Aging
Fibroblasts
Journal Article
Article has an altmetric score of 1392

Word Cloud

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