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Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
2023 Sep-Oct;31 (5): 700-712.

Cutaneous changes in diabetic patients: Primed for aberrant healing?

Vivien Y Chen, Lindsey G Siegfried, Marjana Tomic-Canic, Rivka C Stone, Irena Pastar
Author Information
  1. Vivien Y Chen: Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
  2. Lindsey G Siegfried: Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. ORCID
  3. Marjana Tomic-Canic: Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. ORCID
  4. Rivka C Stone: Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
  5. Irena Pastar: Wound Healing and Regenerative Medicine Research Program, Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA. ORCID
PMID: 37365017 DOI: 10.1111/wrr.13108

Abstract

Cutaneous manifestations affect most patients with diabetes mellitus, clinically presenting with numerous dermatologic diseases from xerosis to diabetic foot ulcers (DFUs). Skin conditions not only impose a significantly impaired quality of life on individuals with diabetes but also predispose patients to further complications. Knowledge of cutaneous biology and the wound healing process under diabetic conditions is largely limited to animal models, and studies focusing on biology of the human condition of DFUs remain limited. In this review, we discuss the critical molecular, cellular, and structural changes to the skin in the hyperglycaemic and insulin-resistant environment of diabetes with a focus specifically on human-derived data. Elucidating the breadth of the cutaneous manifestations coupled with effective diabetes management is important for improving patient quality of life and averting future complications including wound healing disorders.

Keywords

diabetes diabetic foot ulcer glycation hyperglycaemia inflammation neuropathy skin wound healing

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Grants

  1. 1R01DK136241/NIDDK NIH HHS
  2. U01 DK119085/NIDDK NIH HHS
  3. R01 DK136241/NIDDK NIH HHS
  4. 1R61DK131897/NIDDK NIH HHS
  5. R61 DK131897/NIDDK NIH HHS

MeSH Term

Animals
Humans
Wound Healing
Quality of Life
Diabetic Foot
Skin
Diabetes Mellitus
Journal Article Review

Word Cloud

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