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Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
06, 2023;28 (26):

Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent M1 clone, Denmark, 2023.

Thor Bech Johannesen, Charlotte Munkstrup, Sofie Marie Edslev, Sharmin Baig, Stine Nielsen, Tjede Funk, Dennis Karsten Kristensen, Lars Hervig Jacobsen, Signe Fischer Ravn, Niels Bindslev, Sophie Gubbels, Marianne Voldstedlund, Pikka Jokelainen, Søren Hallstrøm, Astrid Rasmussen, Karl Gústaf Kristinsson, David Fuglsang-Damgaard, Ram B Dessau, Agnieszka Barbara Olsén, Christian Salgaard Jensen, Annette Skovby, Svend Ellermann-Eriksen, Thøger Gorm Jensen, Esad Dzajic, Claus Østergaard, Steen Lomborg Andersen, Steen Hoffmann, Peter Henrik Andersen, Marc Stegger
Author Information
  1. Thor Bech Johannesen: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  2. Charlotte Munkstrup: Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
  3. Sofie Marie Edslev: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  4. Sharmin Baig: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  5. Stine Nielsen: Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
  6. Tjede Funk: Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
  7. Dennis Karsten Kristensen: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  8. Lars Hervig Jacobsen: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  9. Signe Fischer Ravn: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  10. Niels Bindslev: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  11. Sophie Gubbels: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  12. Marianne Voldstedlund: Data Integration and Analysis, Statens Serum Institut, Copenhagen, Denmark.
  13. Pikka Jokelainen: Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
  14. Søren Hallstrøm: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  15. Astrid Rasmussen: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  16. Karl Gústaf Kristinsson: Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
  17. David Fuglsang-Damgaard: Department of Clinical Microbiology, Aalborg University Hospital, Aalborg, Denmark.
  18. Ram B Dessau: Department of Regional Health Research, University of Southern Denmark, Odense, Denmark.
  19. Agnieszka Barbara Olsén: Department of Clinical Microbiology, Herlev and Gentofte Hospital - University Hospital, Herlev, Denmark.
  20. Christian Salgaard Jensen: Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
  21. Annette Skovby: Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark.
  22. Svend Ellermann-Eriksen: Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark.
  23. Thøger Gorm Jensen: Department of Clinical Microbiology, Odense University Hospital and Research Unit of Clinical Microbiology, Odense, Denmark.
  24. Esad Dzajic: Clinical Diagnostic Department, Clinical Microbiology, Hospital South West Jutland, University Hospital of Southern Denmark, Esbjerg, Denmark.
  25. Claus Østergaard: Department of Clinical Microbiology, Lillebælt Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
  26. Steen Lomborg Andersen: Department of Clinical Microbiology, Sønderjylland Hospital, University Hospital of Southern Denmark, Aabenraa, Denmark.
  27. Steen Hoffmann: Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
  28. Peter Henrik Andersen: Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, Denmark.
  29. Marc Stegger: Antimicrobial Resistance and Infectious Diseases Laboratory, Harry Butler Institute, Murdoch University, Perth, Australia.
PMID: 37382884 DOI: 10.2807/1560-7917.ES.2023.28.26.2300291

Abstract

A highly virulent sub-lineage of the M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A .

Keywords

Denmark Iceland M1 M1DK Streptococcus pyogenes bacterial genomics group A Streptococcus virulence

References

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MeSH Term

Humans
COVID-19
Streptococcus pyogenes
Seasons
Streptococcal Infections
Denmark
Journal Article
Article has an altmetric score of 83

Word Cloud

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