Bacteria-targeted photothermal therapy for combating drug-resistant bacterial infections.
Hongxin Wei, Liu Yang, Chuming Pang, Liqin Lian, Liangzhi Hong
Author Information
Hongxin Wei: Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China. mslzhong@scut.edu.cn.
Liu Yang: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China.
Chuming Pang: Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China. mslzhong@scut.edu.cn.
Liqin Lian: Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China. mslzhong@scut.edu.cn.
Liangzhi Hong: Faculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China. mslzhong@scut.edu.cn. ORCID
Photothermal therapy is an ideal non-invasive treatment for bacterial infections. However, if photothermal agents are unable to target bacteria, they can also cause thermal damage to healthy tissue. This study describes the fabrication of a TiCT MXene-based photothermal nanobactericide (denoted as MPP) that targets bacteria by modifying MXene nanosheets with polydopamine and the bacterial recognition peptide CAEKA. The polydopamine layer blunts the sharp edges of MXene nanosheets, preventing their damage to normal tissue cells. Furthermore, as a constituent of peptidoglycan, CAEKA can recognize and penetrate the bacterial cell membrane based on similar compatibility. The obtained MPP exhibits superior antibacterial activity and high cytocompatibility compared to the pristine MXene nanosheets. studies showed that MPP colloidal solution under 808 nm NIR light can effectively treat a subcutaneous abscess caused by multi-drug resistant bacterial infection without adverse effects.
