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Molecular medicine reports
Sep, 2023;28 (3):

The NLRP3 inflammasome in viral infection (Review).

Qiaoli Zheng, Chunting Hua, Qichang Liang, Hao Cheng
Author Information
  1. Qiaoli Zheng: Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
  2. Chunting Hua: Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
  3. Qichang Liang: Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
  4. Hao Cheng: Department of Dermatology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China.
PMID: 37417336 DOI: 10.3892/mmr.2023.13047

Abstract

The interplay between pathogen and host determines the immune response during viral infection. The Nod‑like receptor (NLR) protein 3 inflammasome is a multiprotein complex that induces the activation of inflammatory caspases and the release of IL‑1β, which play an important role in the innate immune responses. In the present review, the mechanisms of the NLR family pyrin domain containing 3 inflammasome activation and its dysregulation in viral infection were addressed.

Keywords

NLRP3 inflammasome innate immune response regulation virus infection

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MeSH Term

Humans
Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Virus Diseases
Immunity, Innate
Caspases
Interleukin-1beta

Chemicals

Inflammasomes
NLR Family, Pyrin Domain-Containing 3 Protein
Caspases
Interleukin-1beta
Review Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0infectioninflammasomeimmuneviralresponseNLR3activationinnateNLRP3interplaypathogenhostdeterminesNod‑likereceptorproteinmultiproteincomplexinducesinflammatorycaspasesreleaseIL‑1βplayimportantroleresponsespresentreviewmechanismsfamilypyrindomaincontainingdysregulationaddressedReviewregulationvirus

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