OpenLB
Open Library of Bioscience
Advanced Search
Bioactive materials
Nov, 2023;29 72-84.

Multifunctional magnesium organic framework-based photothermal and pH dual-responsive mouthguard for caries prevention and tooth self-healing promotion.

Qun Li, Jinbiao Liu, Huijie Liu, Yue Sun, Yingying Xu, Kexin Wang, Wenjing Huang, Lan Liao, Xiaolei Wang
Author Information
  1. Qun Li: Affiliated Stomatological Hospital, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
  2. Jinbiao Liu: National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, PR China.
  3. Huijie Liu: Affiliated Stomatological Hospital, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
  4. Yue Sun: College of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi, 330088, PR China.
  5. Yingying Xu: Affiliated Stomatological Hospital, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
  6. Kexin Wang: National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, PR China.
  7. Wenjing Huang: National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, PR China.
  8. Lan Liao: Affiliated Stomatological Hospital, Nanchang University, Nanchang, Jiangxi, 330006, PR China.
  9. Xiaolei Wang: National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi, 330088, PR China.
PMID: 37456578 DOI: 10.1016/j.bioactmat.2023.06.017

Abstract

Caries is considered to be the most prevalent non-communicable disease in humans, mainly deriving from acidogenic bacterial biofilm and resulting in the demineralization and decomposition of hard dental tissue. Herein, a composite responsive foam brace loaded with magnesium organic framework (MPC) is designed for caries prevention and tooth remineralization. MPC can intelligently release organic antibacterial molecules (gallic acid) and mineralized ions (Mg, Ca and PO) under acidic conditions (pH < 5.5) of biofilm infection, regulating pH and killing bacteria. Additionally, due to the excellent photothermal conversion efficiency, MPC can further enhance the destruction of bacterial biofilm by inhibiting virulence genes and destroying bacterial adhesion under near-infrared light irradiation (808 nm). More importantly, MPC can not only reverse the cariogenic environment at both pH and microbial levels, but also promote self-healing of demineralized teeth in terms of both the micro-structure and mechanical properties.

Keywords

Caries prevention Photothermy Remineralization pH-response

References

Bioact Mater. 2021 Dec 20;14:1-14 [PMID: 35310362]
Crit Rev Food Sci Nutr. 2023 Feb 2;:1-21 [PMID: 36728926]
Int J Oral Sci. 2022 Jul 14;14(1):35 [PMID: 35835750]
J Dent Res. 2022 Oct;101(11):1328-1334 [PMID: 35549468]
ACS Nano. 2021 Nov 23;15(11):17842-17853 [PMID: 34761898]
Int J Oral Sci. 2021 Dec 16;13(1):45 [PMID: 34916484]
Food Funct. 2021 Jun 21;12(12):5399-5406 [PMID: 33988204]
ACS Nano. 2022 Feb 22;16(2):3119-3134 [PMID: 35060713]
J Ethnopharmacol. 2021 Jun 28;274:114059 [PMID: 33794333]
Adv Mater. 2021 Apr;33(16):e2004418 [PMID: 33711177]
Bioact Mater. 2022 Mar 16;18:228-241 [PMID: 35387171]
JDR Clin Trans Res. 2022 Apr;7(2):104-117 [PMID: 33797293]
Bioact Mater. 2022 Nov 29;23:394-408 [PMID: 36474660]
Small. 2022 Sep;18(38):e2203644 [PMID: 35989094]
Adv Mater. 2022 Nov;34(46):e2107922 [PMID: 34837252]
Cell. 2020 Apr 2;181(1):29-45 [PMID: 32197064]
ACS Appl Mater Interfaces. 2021 Aug 25;13(33):39142-39156 [PMID: 34433244]
Microb Pathog. 2016 Sep;98:160-6 [PMID: 27432325]
ACS Appl Mater Interfaces. 2022 Jun 29;14(25):28427-28438 [PMID: 35703379]
Mater Horiz. 2023 Feb 6;10(2):512-523 [PMID: 36416286]
Small. 2023 Jan;19(3):e2206657 [PMID: 36394193]
ACS Nano. 2022 Jul 26;16(7):10422-10430 [PMID: 35802535]
J Nanobiotechnology. 2022 Aug 2;20(1):356 [PMID: 35918726]
Nat Rev Endocrinol. 2021 Jun;17(6):336-349 [PMID: 33948016]
JAMA. 2021 Dec 7;326(21):2223 [PMID: 34874417]
Int J Oral Sci. 2021 Dec 7;13(1):42 [PMID: 34876550]
Nat Rev Microbiol. 2022 Oct;20(10):608-620 [PMID: 35922483]
Bioact Mater. 2022 Jun 21;20:418-433 [PMID: 35784637]
Dent Clin North Am. 2010 Jul;54(3):441-54 [PMID: 20630188]
Dent Mater. 2022 Sep;38(9):1518-1531 [PMID: 35907751]
Journal Article

Word Cloud

Similar Articles

Cited By