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Jul 20, 2023;14 (7):

Epidermal Wearable Biosensors for the Continuous Monitoring of Biomarkers of Chronic Disease in Interstitial Fluid.

Xichen Yuan, Oumaima Ouaskioud, Xu Yin, Chen Li, Pengyi Ma, Yang Yang, Peng-Fei Yang, Li Xie, Li Ren
Author Information
  1. Xichen Yuan: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.
  2. Oumaima Ouaskioud: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.
  3. Xu Yin: MOE Key Laboratory of Micro and Nano Systems for Aerospace, School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China.
  4. Chen Li: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.
  5. Pengyi Ma: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.
  6. Yang Yang: Ministry of Education Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing 400030, China.
  7. Peng-Fei Yang: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China. ORCID
  8. Li Xie: Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China.
  9. Li Ren: Key Laboratory of Flexible Electronics of Zhejiang Province, Ningbo Institute of Northwestern Polytechnical University, Ningbo 315103, China.
PMID: 37512763 DOI: 10.3390/mi14071452

Abstract

Healthcare technology has allowed individuals to monitor and track various physiological and biological parameters. With the growing trend of the use of the internet of things and big data, wearable biosensors have shown great potential in gaining access to the human body, and providing additional functionality to analyze physiological and biochemical information, which has led to a better personalized and more efficient healthcare. In this review, we summarize the biomarkers in interstitial fluid, introduce and explain the extraction methods for interstitial fluid, and discuss the application of epidermal wearable biosensors for the continuous monitoring of markers in clinical biology. In addition, the current needs, development prospects and challenges are briefly discussed.

Keywords

chronic disease epidermis interstitial fluid wearable biosensor

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Grants

  1. 52205601/National Natural Science Foundation of China
  2. 82272966/National Natural Science Foundation of China
  3. 202003N4047/Ningbo Natural Science Foundation of China
  4. 2023-YBSF-302/Key R&D Project in Shaanxi Province of China
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