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Cardiovascular & hematological agents in medicinal chemistry
2024;22 (2): 114-120.

Autophagy Behavior under Local Hypothermia in Myocardiocytes Injury.

Basheer Abdullah Marzoog
Author Information
  1. Basheer Abdullah Marzoog: World-Class Research Center, Digital Biodesign and Personalized Healthcare, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia. ORCID
PMID: 37534483 DOI: 10.2174/1871525721666230803102554

Abstract

Hypothermia and autophagy are critical regulators of cell homeostasis by regulating intra and intercellular cell communication. Myocardiocyte cryotherapy poses multiple cellular and subcellular effects on the injured cell, including upregulation of autophagy. Autophagy plays a crucial role in modifying cell metabolism by regulating downregulation, reducing reactive oxygen species production, and improving the natural cellular antioxidant defense system. Reduction of reactive oxygen species production and improving natural cellular antioxidant defense system. Therapeutic hypothermia ranges from 32-34��C in terms of local myocardiocyte cooling. Hypothermia induces autophagy by phosphorylating the Akt signaling pathway. Hypothermia has a more therapeutic effect when applied at the beginning of reperfusion rather than in the beginning of ischemia. Moderate hypothermia with 33��C poses most therapeutic effect by viability maintaining and reduction of reactive oxygen species release. Application of local hypothermia to myocardiocytes can be applied to infarcted myocardiocytes, anginal and to the cardiomyopathies.

Keywords

Autophagy cell longevity. hypothermia myocardial infarction pathogenesis & physiopathology regeneration

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Grants

  1. 075-15-2022-304/Ministry of Science and Higher Education of the Russian Federation

MeSH Term

Autophagy
Humans
Animals
Myocytes, Cardiac
Hypothermia, Induced
Reactive Oxygen Species

Chemicals

Reactive Oxygen Species
Journal Article Review

Word Cloud

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