Etiological relationship between lipid metabolism and endometrial carcinoma.
Wenzhe Li, Yi Xu, Xinling Zeng, Jie Tan, Ya Wang, Hongyan Wu, Maokun Li, Cunjian Yi
Author Information
Wenzhe Li: Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Yi Xu: Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Xinling Zeng: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Jie Tan: Department of Hematology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Ya Wang: Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China. wangya@yangtzeu.edu.cn.
Hongyan Wu: Department of Endocrinology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China.
Maokun Li: Department of Hubei Provincial Clinical Research Center for Personalized Diagnosis and Treatment of Cancer, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China. maokunli09@126.com.
Cunjian Yi: Department of Gynecology and Obstetrics, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, China. cunjiany@yangtzeu.edu.cn.
Endometrial carcinoma (EC) has become one of the most common gynecological malignant neoplasms in developed countries worldwide. Studies have shown that this may be closely related to the abnormal metabolism of blood lipids, which was the most significant metabolic change in the human body in this cancer. In this review, we focus on the correlation between lipid metabolism and EC and discuss the evidence that abnormal lipid metabolism promotes an increase in EC growth and metabolism, as well as the regulatory mechanism and related signaling pathways involved in this relationship. In addition, we also discussed the research progress of targeted therapies and drug treatments for EC that act on lipid metabolism, and statins are expected to become adjuvant drugs for EC in the future. This review will provide a systematic view for a better understanding of the etiological relationship between lipid metabolism and EC and further open up new therapeutic possibilities and effective treatments for EC by targeting lipid metabolism.
