Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen.
Joseph Jelinski, Monika M Kowatsch, Marc-Alexandre Lafrance, Alice Berger, Jannie Pedersen, Hiva Azizi, Yue Li, Florine Scholte, Alejandro Gomez, Natasha Hollett, Toby Le, Matthew Wade, Hugues Fausther-Bovendo, Marc-Antoine de La Vega, George Babuadze, Ara Xiii, Claude Lamarre, Trina Racine, Chil-Yong Kang, Xiao-Jian Yao, Galit Alter, Eric Arts, Keith R Fowke, Gary P Kobinger
Author Information
Joseph Jelinski: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Monika M Kowatsch: Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Marc-Alexandre Lafrance: Faculty of Medicine, Université Laval, Quebec City, Canada.
Alice Berger: Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Canada.
Jannie Pedersen: Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, Canada.
Hiva Azizi: Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Canada.
Yue Li: Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Florine Scholte: Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Canada.
Alejandro Gomez: Département de Microbiologie-Infectiologie et Immunologie, Faculté de Médecine, Université Laval, Québec, Canada.
Natasha Hollett: Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Toby Le: Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Matthew Wade: Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, Canada.
Hugues Fausther-Bovendo: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Marc-Antoine de La Vega: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
George Babuadze: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Ara Xiii: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Claude Lamarre: Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, Canada.
Trina Racine: Axe des Maladies Infectieuses et Immunitaires, Centre de Recherche du Centre Hospitalier Universitaire de Québec-Université Laval, Québec, Canada.
Chil-Yong Kang: Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Xiao-Jian Yao: Department of Medical Microbiology, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
Galit Alter: Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
Eric Arts: Department of Microbiology and Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Keith R Fowke: Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.
Gary P Kobinger: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Despite the human immunodeficiency virus (HIV) pandemic continuing worldwide for 40 years, no vaccine to combat the disease has been licenced for use in at risk populations. Here, we describe a novel recombinant vesicular stomatitis virus (rVSV) vector vaccine expressing modified HIV envelope glycoproteins and Ebola virus glycoprotein. Three heterologous immunizations successfully prevented infection by a different clade SHIV in 60% of non-human primates (NHPs). No trend was observed between resistance and antibody interactions. Resistance to infection was associated with high proportions of central memory T-cell CD69 and CD154 marker upregulation, increased IL-2 production, and a reduced IFN-γ response, offering insight into correlates of protection.
