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Cell death discovery
Sep 04, 2023;9 (1): 330.

Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention.

Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan
Author Information
  1. Zhenyu Zhang: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. ORCID
  2. Minnan Chen: Nantong First People's Hospital, Nantong, 226001, China.
  3. Wenjing Zhan: The Key Laboratory of Anti-Inflammatory and Immune Medicine, Anhui Medical University, Hefei, 230032, China.
  4. Yuechun Chen: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
  5. Tongtong Wang: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
  6. Zhonghua Chen: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
  7. Yifei Fu: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China.
  8. Gang Zhao: Orthopaedic Institute, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China.
  9. Dong Mao: Orthopaedic Institute, Wuxi 9th People's Hospital Affiliated to Soochow University, Wuxi, 214062, China. maodong3344@suda.edu.cn. ORCID
  10. Jingjing Ruan: Nantong First People's Hospital, Nantong, 226001, China. ruan-jingjing@hotmail.com. ORCID
  11. Feng-Lai Yuan: Institute of Integrated Chinese and Western Medicine, Affiliated to Jiangnan University, Wuxi, Jiangsu, 214041, China. bjjq88@jiangnan.edu.cn. ORCID
PMID: 37666823 DOI: 10.1038/s41420-023-01624-6

Abstract

Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.

References

  1. Pflugers Arch. 2023 Mar;475(3):405-416 [PMID: 36522586]
  2. Biores Open Access. 2018 Feb 01;7(1):2-9 [PMID: 29445584]
  3. Adv Exp Med Biol. 2018;1099:37-47 [PMID: 30306513]
  4. Cell Death Dis. 2022 Aug 12;13(8):702 [PMID: 35961983]
  5. Toxins (Basel). 2020 Apr 20;12(4): [PMID: 32326130]
  6. J Physiol. 2003 Jan 1;546(Pt 1):77-87 [PMID: 12509480]
  7. Osteoarthritis Cartilage. 2018 Jan;26(1):138-148 [PMID: 29061494]
  8. J Neuroinflammation. 2015 Dec 30;12:246 [PMID: 26715049]
  9. J Cancer. 2020 Jun 28;11(17):5135-5149 [PMID: 32742461]
  10. Clin Orthop Relat Res. 1993 Aug;(293):372-7 [PMID: 8339506]
  11. J Biol Chem. 2010 May 21;285(21):16315-29 [PMID: 20299463]
  12. Neuroscience. 2009 Aug 4;162(1):55-66 [PMID: 19376200]
  13. Adv Sci (Weinh). 2023 Sep;10(26):e2303246 [PMID: 37409440]
  14. Cells. 2021 Aug 10;10(8): [PMID: 34440817]
  15. Biomolecules. 2023 Mar 10;13(3): [PMID: 36979442]
  16. Pharmacol Ther. 2010 Dec;128(3):549-58 [PMID: 20807551]
  17. J Gen Physiol. 2006 Mar;127(3):267-76 [PMID: 16505147]
  18. Nature. 1997 Mar 13;386(6621):173-7 [PMID: 9062189]
  19. Drug Resist Updat. 2020 Sep;52:100712 [PMID: 32599435]
  20. Channels (Austin). 2019 Dec;13(1):367-373 [PMID: 31526163]
  21. Nature. 2007 Sep 20;449(7160):316-23 [PMID: 17882215]
  22. Nat Commun. 2020 Jan 24;11(1):475 [PMID: 31980622]
  23. Nat Rev Nephrol. 2012 Oct;8(10):589-601 [PMID: 22945490]
  24. Front Pharmacol. 2022 Dec 15;13:996667 [PMID: 36588718]
  25. Nat Rev Clin Oncol. 2020 Jul;17(7):395-417 [PMID: 32203277]
  26. Phys Chem Chem Phys. 2022 Jun 8;24(22):13824-13830 [PMID: 35616206]
  27. J Biol Chem. 1997 Nov 14;272(46):28819-22 [PMID: 9360943]
  28. J Gen Physiol. 2014 Sep;144(3):245-55 [PMID: 25114023]
  29. J Neurochem. 2020 Apr;153(2):203-215 [PMID: 31976561]
  30. Environ Sci Technol. 2021 Nov 2;55(21):14863-14875 [PMID: 34677944]
  31. J Inflamm Res. 2021 Mar 12;14:843-858 [PMID: 33737825]
  32. Mol Brain. 2013 Jan 02;6:1 [PMID: 23281934]
  33. Trends Immunol. 2022 Dec;43(12):969-977 [PMID: 36319537]
  34. Cell Mol Life Sci. 2021 Dec;78(24):8109-8125 [PMID: 34778915]
  35. IUBMB Life. 2008 Sep;60(9):620-8 [PMID: 18459164]
  36. J Cell Mol Med. 2022 May;26(10):2777-2792 [PMID: 35426224]
  37. Trends Neurosci. 2006 Oct;29(10):578-86 [PMID: 16891000]
  38. Cell Death Differ. 2013 Oct;20(10):1359-69 [PMID: 23852371]
  39. Int J Oncol. 2021 Oct;59(4): [PMID: 34515325]
  40. Curr Pharm Des. 2022;28(17):1406-1411 [PMID: 35466865]
  41. NMR Biomed. 2018 Apr;31(4):e3892 [PMID: 29380927]
  42. Lab Invest. 2022 Aug;102(8):859-871 [PMID: 35292759]
  43. Adv Neurol. 1996;71:209-33; discussion 234-6 [PMID: 8790801]
  44. Neuropsychiatr Dis Treat. 2022 Sep 25;18:2181-2198 [PMID: 36187562]
  45. Expert Opin Ther Targets. 2014 Jan;18(1):1-14 [PMID: 24261866]
  46. Research (Wash D C). 2023 Jun 01;6:0105 [PMID: 37275123]
  47. Curr Opin Pharmacol. 2008 Feb;8(1):25-32 [PMID: 17945532]
  48. Biology (Basel). 2020 Dec 11;9(12): [PMID: 33322264]
  49. Int Immunopharmacol. 2015 Dec;29(2):748-760 [PMID: 26359543]
  50. Neuropharmacology. 2006 Jun;50(8):964-74 [PMID: 16549075]
  51. Gene. 2018 Feb 5;642:230-240 [PMID: 29141196]
  52. Cerebrovasc Dis. 2004;17 Suppl 1:153-66 [PMID: 14694293]
  53. Eur J Pharmacol. 2022 Nov 5;934:175296 [PMID: 36162458]
  54. Front Oncol. 2022 Jun 28;12:904742 [PMID: 35837090]
  55. Mar Drugs. 2018 Dec 12;16(12): [PMID: 30545037]
  56. Elife. 2019 May 02;8: [PMID: 31045491]
  57. Endocr J. 2014;61(2):101-10 [PMID: 24088601]
  58. Acta Pharmacol Sin. 2007 Nov;28(11):1731-6 [PMID: 17959023]
  59. J Transl Med. 2022 Dec 3;20(1):561 [PMID: 36463203]
  60. Mol Cell Endocrinol. 2020 Apr 5;505:110742 [PMID: 32006608]
  61. Acta Biochim Biophys Sin (Shanghai). 2014 Sep;46(9):774-81 [PMID: 25079679]
  62. Lancet. 2016 Oct 22;388(10055):2023-2038 [PMID: 27156434]
  63. Int J Physiol Pathophysiol Pharmacol. 2010 Mar 18;2(2):73-94 [PMID: 21383888]
  64. J Neurosci. 2003 Jul 2;23(13):5496-502 [PMID: 12843249]
  65. Cell Biol Int. 2012 Jul;36(7):635-41 [PMID: 22168390]
  66. J Cell Mol Med. 2019 Nov;23(11):7879-7884 [PMID: 31508906]
  67. FEBS J. 2017 Feb;284(4):525-545 [PMID: 27580245]
  68. Mol Vis. 2011;17:3300-8 [PMID: 22194656]
  69. Int J Mol Sci. 2017 Oct 11;18(10): [PMID: 29019932]
  70. Physiol Rep. 2023 Mar;11(6):e15654 [PMID: 36967457]
  71. Int Immunopharmacol. 2020 Mar 5;82:106340 [PMID: 32146316]
  72. Annu Rev Physiol. 2019 Feb 10;81:375-402 [PMID: 30485762]
  73. J Neurosci. 2004 Feb 4;24(5):1005-12 [PMID: 14762118]
  74. Cell Death Differ. 2022 Jul;29(7):1318-1334 [PMID: 35726022]
  75. Nat Mater. 2023 Mar;22(3):391-399 [PMID: 36864161]
  76. Small Methods. 2023 May 18;:e2300278 [PMID: 37203269]
  77. FEBS Lett. 1998 Aug 21;433(3):257-60 [PMID: 9744806]
  78. JAMA. 2023 Feb 21;329(7):574-587 [PMID: 36809318]
  79. Am J Physiol. 1999 Jun;276(6):C1405-10 [PMID: 10362604]
  80. J Cell Mol Med. 2019 May;23(5):3429-3440 [PMID: 30793492]
  81. Am J Physiol Cell Physiol. 2002 Jul;283(1):C126-34 [PMID: 12055080]
  82. Nat Rev Gastroenterol Hepatol. 2018 Dec;15(12):738-752 [PMID: 30250076]
  83. Glia. 2021 Mar;69(3):746-764 [PMID: 33090575]
  84. J Physiol. 2021 Nov;599(21):4749-4762 [PMID: 34487355]
  85. Iran J Basic Med Sci. 2016 Aug;19(8):812-820 [PMID: 27746861]
  86. Cells. 2020 Apr 03;9(4): [PMID: 32260219]
  87. Mol Immunol. 2023 Jan;153:25-35 [PMID: 36403431]
  88. Inflamm Res. 2010 Nov;59(11):939-47 [PMID: 20454829]
  89. Cell Metab. 2023 Aug 8;35(8):1424-1440.e5 [PMID: 37413991]
  90. Neuropharmacology. 2015 Jul;94:87-98 [PMID: 25592213]
  91. Membranes (Basel). 2022 Jan 20;12(2): [PMID: 35207041]
  92. Chembiochem. 2011 Apr 11;12(6):830-9 [PMID: 21472911]
  93. Annu Rev Immunol. 2018 Apr 26;36:489-517 [PMID: 29400998]
  94. Mol Cell Biochem. 2010 Jul;340(1-2):153-9 [PMID: 20179994]
  95. J Urol. 2011 Oct;186(4):1509-16 [PMID: 21855903]
  96. Am J Physiol Renal Physiol. 2020 Mar 1;318(3):F531-F543 [PMID: 31984789]
  97. Connect Tissue Res. 2014 Jun;55(3):197-204 [PMID: 24432912]
  98. Cell Metab. 2023 Jul 11;35(7):1101-1113 [PMID: 37390822]
  99. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2326-31 [PMID: 11842212]
  100. Cancers (Basel). 2020 Jul 08;12(7): [PMID: 32650495]
  101. J Biol Chem. 2001 Sep 7;276(36):33782-7 [PMID: 11448963]
  102. Ageing Res Rev. 2023 Jan;83:101785 [PMID: 36371015]
  103. Biomedicines. 2021 Sep 26;9(10): [PMID: 34680442]
  104. Am J Physiol. 1991 Mar;260(3 Pt 2):R581-8 [PMID: 2001008]
  105. Mediators Inflamm. 2014;2014:712962 [PMID: 25197168]
  106. Sci Rep. 2019 May 27;9(1):7863 [PMID: 31133660]
  107. Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):162-177 [PMID: 28986307]
  108. Inflamm Res. 2012 Apr;61(4):327-35 [PMID: 22237475]
  109. Neurosci Biobehav Rev. 2022 Apr;135:104581 [PMID: 35181397]
  110. J Neurosci. 2004 Feb 4;24(5):1013-22 [PMID: 14762119]
  111. J Gen Physiol. 2023 Feb 6;155(2): [PMID: 36484717]
  112. J Biol Chem. 2014 May 9;289(19):13363-73 [PMID: 24695733]
  113. Mol Cell Biochem. 2018 Jun;443(1-2):181-191 [PMID: 29273849]
  114. Eur J Pharmacol. 2021 Sep 15;907:174252 [PMID: 34116040]
  115. Curr Eye Res. 2018 Jul;43(7):921-933 [PMID: 29595330]
  116. Cancer Cell. 2023 Mar 13;41(3):573-580 [PMID: 36917953]
  117. Nat Med. 2023 Jun;29(6):1424-1436 [PMID: 37280275]
  118. Temperature (Austin). 2023 Mar 29;10(1):136-154 [PMID: 37187834]
  119. Int Orthop. 2015 Jan;39(1):149-59 [PMID: 25117574]
  120. J Biol Chem. 2003 Apr 25;278(17):15023-34 [PMID: 12584187]
  121. Elife. 2020 Feb 07;9: [PMID: 32031522]
  122. Acta Pharmacol Sin. 2007 Oct;28(10):1621-7 [PMID: 17883949]
  123. Front Physiol. 2022 Jan 31;13:831830 [PMID: 35173633]
  124. Biosci Rep. 2019 Nov 29;39(11): [PMID: 31696219]
  125. Microvasc Res. 2008 Mar;75(2):202-10 [PMID: 17936312]
  126. Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193 [PMID: 30655609]
  127. Curr Neuropharmacol. 2021;19(9):1570-1589 [PMID: 33550975]
  128. Biomolecules. 2020 Sep 02;10(9): [PMID: 32887365]
  129. Biochem Biophys Res Commun. 2005 Nov 11;337(1):349-54 [PMID: 16185661]
  130. Nat Rev Clin Oncol. 2023 Apr;20(4):250-264 [PMID: 36806788]
  131. Br J Pharmacol. 1996 Jun;118(3):748-54 [PMID: 8762103]
  132. Semin Cancer Biol. 2023 Jan;88:32-45 [PMID: 36496155]
  133. Acta Physiol (Oxf). 2011 Jan;201(1):97-107 [PMID: 20969730]
  134. BJU Int. 2009 Dec;104(11):1746-51 [PMID: 19493263]
  135. Biochem Biophys Res Commun. 2009 Feb 20;379(4):824-9 [PMID: 19133233]
  136. J Hepatol. 2023 Aug;79(2):538-551 [PMID: 36893854]
  137. ACS Nano. 2018 Dec 26;12(12):12357-12368 [PMID: 30418752]
  138. PLoS One. 2018 May 21;13(5):e0196894 [PMID: 29782492]
  139. Cell Prolif. 2021 Jan;54(1):e12941 [PMID: 33111436]
  140. Nat Commun. 2011 Jul 19;2:399 [PMID: 21772270]
  141. Orthop Clin North Am. 2011 Oct;42(4):585-601, ix [PMID: 21944594]
  142. Eur J Pharmacol. 2021 Feb 15;893:173816 [PMID: 33345857]
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