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Nano letters
09 27, 2023;23 (18): 8664-8673.

Transient Dynamic Operation of G-Quadruplex-Gated Glucose Oxidase-Loaded ZIF-90 Metal-Organic Framework Nanoparticle Bioreactors.

Yunlong Qin, Yu Ouyang, Jianbang Wang, Xinghua Chen, Yang Sung Sohn, Itamar Willner
Author Information
  1. Yunlong Qin: The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  2. Yu Ouyang: The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. ORCID
  3. Jianbang Wang: The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  4. Xinghua Chen: The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  5. Yang Sung Sohn: The Institute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
  6. Itamar Willner: The Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. ORCID
PMID: 37669541 DOI: 10.1021/acs.nanolett.3c02542

Abstract

Glucose oxidase-loaded ZIF-90 metal-organic framework nanoparticles conjugated to hemin-G-quadruplexes act as functional bioreactor hybrids operating transient dissipative biocatalytic cascaded transformations consisting of the glucose-driven HO-mediated oxidation of Amplex-Red to resorufin or the glucose-driven generation of chemiluminescence by the HO-mediated oxidation of luminol. One system involves the fueled activation of a reaction module leading to the temporal formation and depletion of the bioreactor conjugate operating the nickase-guided transient biocatalytic cascades. The second system demonstrates the fueled activation of a reaction module yielding a bioreactor conjugate operating the exonuclease III-dictated transient operation of the two biocatalytic cascades. The temporal operations of the bioreactor circuits are accompanied by kinetic models and computational simulations enabling us to predict the dynamic behavior of the systems subjected to different auxiliary conditions.

Keywords

Biocatalytic cascade Chemiluminescence DNA DNAzyme Dissipative circuit Strand displacement

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MeSH Term

Glucose Oxidase
DNA, Catalytic
Metal-Organic Frameworks
G-Quadruplexes
Hydrogen Peroxide
Glucose
Nanoparticles
Bioreactors
Hemin
Biosensing Techniques

Chemicals

Glucose Oxidase
DNA, Catalytic
Metal-Organic Frameworks
Hydrogen Peroxide
ZIF-90
Glucose
Hemin
Journal Article Research Support, Non-U.S. Gov't
Article has an altmetric score of 2

Word Cloud

Created with Highcharts 10.0.0bioreactoroperatingtransientbiocatalyticGlucoseZIF-90glucose-drivenHO-mediatedoxidationsystemfueledactivationreactionmoduletemporalconjugatecascadesoxidase-loadedmetal-organicframeworknanoparticlesconjugatedhemin-G-quadruplexesactfunctionalhybridsdissipativecascadedtransformationsconsistingAmplex-RedresorufingenerationchemiluminescenceluminolOneinvolvesleadingformationdepletionnickase-guidedseconddemonstratesyieldingexonucleaseIII-dictatedoperationtwooperationscircuitsaccompaniedkineticmodelscomputationalsimulationsenablinguspredictdynamicbehaviorsystemssubjecteddifferentauxiliaryconditionsTransientDynamicOperationG-Quadruplex-GatedOxidase-LoadedMetal-OrganicFrameworkNanoparticleBioreactorsBiocatalyticcascadeChemiluminescenceDNADNAzymeDissipativecircuitStranddisplacement

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