Chun-Li Tang: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Zheng Zhu: Department of Allergy and Clinical Immunology, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, Guangzhou, China.
Chang-Hao Zhong: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Zi-Qing Zhou: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Hui-Qi Zhou: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Rong-Mei Geng: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Xiao-Bo Chen: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Yu Chen: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China.
Shi-Yue Li: Department of Respiratory and Critical Care Medicine, National Center for Respiratory Medicine, State Key Lab of Respiratory Disease, The first affiliated hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, China. lishiyue@188.com.
BACKGROUND: Endobronchial ultrasonography-guided transbronchial needle aspiration biopsy (EBUS-TBNA) has been used for more than 10 years in China. Its clinical application and diagnostic value in different diseases with large sample was lack of report. METHODS: A retrospective analysis was performed about the application and diagnostic value of EBUS-TBNA in different disease of patients in Respiratory Intervention Center of Guangzhou Institute of Respiratory Health from January 2012 to July 2020. RESULTS: A total 5758 patients were included with 182 patients excluded for lack of information. Finally, data of 5576 patients (3798 males and 1778 females) were analyzed. For anesthetize, most patients were undergoing general anesthesia of intravenous with spontaneous breathing (69.4%), followed by general anesthesia of intravenous and inhalation with tracheal intubation and mechanical ventilation (17.9%) and conscious sedation and analgesia (12.8%). Lymph nodes were the main sites of biopsy obtained (76.4%). Tumors accounted for the highest proportion of disease (66.4%), followed by infection diseases (9.9%), sarcoidosis (3.9%), lymphoma (1.1%), and others (18.7%). The sensitivity of EBUS-TBNA for diagnosis of tumor was 89.7%, and 40.8% for infection diseases. There were significant differences in the puncture site and proportions of diseases between male and females (both p < 0.05). Higher diagnostic value was found in male patients (p < 0.05). CONCLUSION: EBUS-TBNA has good diagnostic value for different mediastinal and central pulmonary space-occupying lesions diseases, with highest sensitivity for tumors. Higher diagnostic value was found in male patients.
