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American journal of physiology. Cell physiology
11 01, 2023;325 (5): C1201-C1211.

Signaling circuits and the apical extracellular matrix in aging: connections identified in the nematode .

Hannah Reich, Cathy Savage-Dunn
Author Information
  1. Hannah Reich: Department of Biology, Queens College, City University of New York, Flushing, New York, United States.
  2. Cathy Savage-Dunn: Department of Biology, Queens College, City University of New York, Flushing, New York, United States. ORCID
PMID: 37721005 DOI: 10.1152/ajpcell.00195.2023

Abstract

Numerous conserved signaling pathways play critical roles in aging, including insulin/IGF-1, TGF-β, and Wnt pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidirectional relationship between these factors and providing a platform to address how regulation of and by the extracellular matrix can impact lifespan and organismal health during aging. These discoveries provide new opportunities for clinical advances and novel therapeutic strategies.

Keywords

Caenorhabditis elegans aging cell signaling cuticle extracellular matrix

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Grants

  1. R15 GM112147/NIGMS NIH HHS
  2. R21 AG075315/NIA NIH HHS

MeSH Term

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Aging
Longevity
Wnt Signaling Pathway

Chemicals

Caenorhabditis elegans Proteins
Journal Article Review Research Support, N.I.H., Extramural
Article has an altmetric score of 4

Word Cloud

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