Access to palliative care in patients with advanced cancer of the uterine cervix in the low- and middle-income countries: a systematic review.

Francis Ooko, Tebogo Mothiba, Peter Van Bogaert, Johan Wens
Author Information
  1. Francis Ooko: Faculty of Health Sciences, University of Limpopo, Private Bag X1106, Sovenga, 0727, South Africa. francis.ooko@ul.ac.za.
  2. Tebogo Mothiba: Faculty of Health Sciences, University of Limpopo, Private Bag X1106, Sovenga, 0727, South Africa.
  3. Peter Van Bogaert: Faculty of Medicine and Health Sciences, University of Antwerp, Prinsstraat 13, Antwerp, 2000, Belgium.
  4. Johan Wens: Faculty of Medicine and Health Sciences, University of Antwerp, Prinsstraat 13, Antwerp, 2000, Belgium.

Abstract

BACKGROUND: Women with advanced uterine cervical cancer suffer from a combination of moderate to severe physical, psychological, social, and spiritual distress due to their disease and are in need of palliative care to improve their quality of life. Approximately 85% of the women live in the low- and middle-income countries. Whether these women and their families access palliative care is not known.
OBJECTIVES: To understand the geographic accessibility, availability, financial accessibility, and acceptability of palliative care by patients with advanced cervical cancer and their families.
METHODS: We conducted a Systematic review following PRISMA guidelines in CINAHL, Cochrane Central Register of Controlled Trials, MEDLINE, PsychINFO, PubMed and Scopus for the core concepts: palliative care, access, advanced uterine cervical cancer. Eligible articles were published in English, contained original data on experiences of patients and/or caregivers including symptoms management, and discussed available resources, communication, satisfaction, and healthcare utilization.
RESULTS: Overall there was limited access to palliative care with the few available facilities located in cities, far from the rural areas where most women lived. Pervasive poverty was common with poor affordability of healthcare, travelling, accommodation, and subsistence expenses. Misconceptions and poor knowledge of the disease, cultural beliefs and attitudes, and other health system insufficiencies also presented challenges for access.
CONCLUSION: Concerted effort should be made to improve availability of palliative care facilities. Health education to address misconceptions and other cognitive barriers that limit access among cervical cancer patients and their families should be urgently undertaken in the LMICs.

Keywords

References

  1. Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, et al. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis. The Lancet Global Health. 2020;8(2):e191–e203. [DOI: 10.1016/S2214-109X(19)30482-6]
  2. Krakauer EL, Kwete X, Kane K, Afshan G, Bazzett-Matabele L, Bien-Aimé DDR, et al. Cervical cancer-associated suffering: estimating the palliative care needs of a highly vulnerable population. JCO Global Oncology. 2021;7:862–72. [PMID: 34115522]
  3. Paul R, Musa G, Chungu H. Prevalence of depression among cervical cancer patients seeking treatment at the cancer diseases hospital. IOSR J Dent Med Sci Ver XI. 2016;15(6):2279–861.
  4. Bates MJ, Gordon MR, Gordon SB, Tomeny EM, Muula AS, Davies H, et al. Palliative care and catastrophic costs in Malawi after a diagnosis of advanced cancer: a prospective cohort study. The Lancet Global Health. 2021;9(12):e1750–e7.
  5. Krakauer EL, Kane K, Kwete X, Afshan G, Bazzett-Matabele L, Ruthnie Bien-Aimé DD, et al. Essential Package of Palliative Care for Women with Cervical Cancer: responding to the suffering of a highly vulnerable Population. JCO Glob Oncol. 2021;7:873–85. [PMID: 34115527]
  6. Miller BE, Pittman B, Strong C. Gynecologic cancer patients’ psychosocial needs and their views on the physician’s role in meeting those needs. Int J Gynecol Cancer. 2003;13(2):111–9. [PMID: 12657109]
  7. Maree JE, Langley G, Nqubezelo L. Not a nice experience, not at all: underprivileged women’s experiences of being confronted with cervical cancer. Palliat Support Care. 2015;13(2):239–47. [PMID: 24524195]
  8. Allende-Perez S, Dominguez-Ocadio G, Velez-Salas V, Isla-Ortiz D, Peña-Nieves A, Verastegui E. Snapshot of symptoms of advanced cervical cancer patients referred to the palliative care service in a cancer center in Mexico. Int J Gynaecol Obstet. 2021;153(2):335–9. [PMID: 33184853]
  9. Radbruch L, De Lima L, Knaul F, Wenk R, Ali Z, Bhatnaghar S, et al. Redefining palliative care—A new consensus-based definition. J Pain Symptom Manag. 2020;60(4):754–64.
  10. Temel JS, Greer JA, Muzikansky A, Gallagher ER, Admane S, Jackson VA, et al. Early palliative care for patients with metastatic non–small-cell lung cancer. N Engl J Med. 2010;363(8):733–42. [PMID: 20818875]
  11. Temel JS, Greer JA, Admane S, Gallagher ER, Jackson VA, Lynch TJ, et al. Longitudinal perceptions of prognosis and goals of therapy in patients with metastatic non–small-cell lung cancer: results of a randomized study of early palliative care. J Clin Oncol. 2011;29(17):2319–26. [PMID: 21555700]
  12. El-Jawahri A, Greer JA, Temel JS. Does palliative care improve outcomes for patients with incurable illness? A review of the evidence. Database of abstracts of reviews of Effects (DARE). Quality-assessed Reviews [Internet]; 2011.
  13. Teno JM, Casarett D, Spence C, Connor S. It is too late or is it? Bereaved family member perceptions of hospice referral when their family member was on hospice for seven days or less. J Pain Symptom Manag. 2012;43(4):732–8.
  14. Hui D, Kim S-H, Kwon JH, Tanco KC, Zhang T, Kang JH, et al. Access to palliative care among patients treated at a comprehensive cancer center. Oncologist. 2012;17(12):1574. [PMID: 23220843]
  15. Abel J, Kellehear A, Mills J, Patel M. Access to palliative care reimagined. Future Healthc J. 2021;8(3):e699. [PMID: 34888470]
  16. Alkhudairi HM. General public awareness, knowledge, and beliefs toward palliative care in a saudi population. J Nat Sci Med. 2019;2(1):48.
  17. Pinto E, Gonçalves F, Sacarlal J, Castro L, Rego G. Pain management in cancer patients in the main hospitals in Mozambique. Ann Palliat Med. 2021;10(4):4069–79. [PMID: 33894734]
  18. Tapera O, Nyakabau AM. Limited knowledge and access to palliative care among women with cervical cancer: an opportunity for integrating oncology and palliative care in Zimbabwe. BMC Palliat Care. 2020;19(1):1–9.
  19. Islam JY, Deveaux A, Previs RA, Akinyemiju T. Racial and ethnic disparities in palliative care utilization among gynecological cancer patients. Gynecol Oncol. 2021;160(2):469–76. [PMID: 33276985]
  20. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Syst Reviews. 2021;10(1):1–11.
  21. Von Elm E., Altman DG, Egger M, Pockok SJ, Gotzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guideline for reporting observational studies. The Lancet. 2007; 370(9596):1453–7.
  22. O’Brien BC, Harris IB, Beckman TJ, Reed DA, Cook DA. Standards for reporting qualitative research: a synthesis of recommendations. Acad Med. 2014;89(9):1245–51. [PMID: 24979285]
  23. Lucas PJ, Baird J, Arai L, Law C, Roberts HM. Worked examples of alternative methods for the synthesis of qualitative and quantitative research in systematic reviews. BMC Med Res Methodol. 2007;7(1):1–7.
  24. Peters DH, Garg A, Bloom G, Walker DG, Brieger WR, Hafizur Rahman M. Poverty and access to health care in developing countries. Ann N Y Acad Sci. 2008;1136(1):161–71. [PMID: 17954679]
  25. Tapera O, Dreyer G, Nyakabau AM, Kadzatsa W, Stray-Pedersen B, Hendricks SJH. Model strategies to address barriers to cervical cancer treatment and palliative care among women in Zimbabwe: a public health approach. BMC Womens Health. 2021;21(1):1–11.
  26. Tapera O, Kadzatsa W, Nyakabau AM, Mavhu W, Dreyer G, Stray-Pedersen B, Sjh H. Sociodemographic inequities in cervical cancer screening, treatment and care among women aged at least 25 years: evidence from surveys in Harare, Zimbabwe. BMC Public Health. 2019; 19(1):1–2.
  27. Miranda B, Vidal SA, Mello MJ, Lima JT, Rego JC, Pantaleao MC, et al. Cancer patients, emergency service and provision of palliative care. Revista da Associacao Medica Brasileira. 2016;62:207–11. [PMID: 27310542]
  28. Dutta S, Biswas N, Muhkherjee G. Evaluation of socio-demographic factors for non-compliance to treatment in locally advanced cases of cancer cervix in a rural medical college hospital in India. Indian journal of palliative care. 2013; 19(3):158.
  29. Kebebew T, Mosalo A, Mavhandu-Mudzusi AH. Caregivers’ satisfaction with cervical cancer care in Ethiopia. Supportive Care in Cancer. 2022; 30(9):7597–603. [PMID: 35674793]
  30. Noor-Mahomed SB, Schlebusch L, Bosch BA. Suicidal behavior in patients diagnosed with cancer of the cervix. Crisis: The Journal of Crisis Intervention and Suicide Prevention. 2003;24(4):168.
  31. Mwaka AD, Wabinga HR, Mayanja-Kizza H. Mind the gaps: a qualitative study of perceptions of healthcare professionals on challenges and proposed remedies for cervical cancer help-seeking in post conflict northern Uganda. BMC Fam Pract. 2013;14:193. [PMID: 24341601]
  32. van Schalkwyk SL, Maree JE, Wright SC. Cervical cancer: the route from signs and symptoms to treatment in South Africa. Reprod Health Matters. 2008;16(32):9–17. [PMID: 19027618]
  33. Kebede BG, Abraha A, Andersson R, et al. Communicative challenges among physicians, patients, and family caregivers in cancer care: an exploratory qualitative study in Ethiopia. PloS one. 2020;15(3):e0230309. [PMID: 32168353]
  34. Tapera O, Dreyer G, Kadzatsa W, Nyakabau AM, Stray-Pedersen B, Hendricks SJH. Determinants of access and utilization of cervical cancer treatment and palliative care services in Harare, Zimbabwe. BMC Public Health. 2019;19(1):NPAG–NPAG.
  35. Rhee JY, Garralda E, Torrado C, Blanco S, Ayala I, Namisango E, et al. Palliative care in Africa: a scoping review from 2005–16. Lancet Oncol. 2017;18(9):e522–e31. [PMID: 28884701]
  36. Lynch T, Connor S, Clark D. Mapping levels of palliative care development: a global update. J Pain Symptom Manag. 2013;45(6):1094–106.
  37. Powell RA, Harding R, Namisango E, Katabira E, Gwyther L, Radbruch L, et al. Palliative care research in Africa: an overview. Eur J Palliat Care. 2013;20(4):162–7.
  38. Ferrell BR, Temel JS, Temin S, Alesi ER, Balboni TA, Basch EM, et al. Integration of palliative care into standard oncology care: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017;35(1):96–112. [PMID: 28034065]
  39. Islam JY, Saraiya V, Previs RA, Akinyemiju T. Health Care Access Measures and Palliative Care Use by Race/Ethnicity among metastatic gynecological Cancer patients in the United States. Int J Environ Res Public Health. 2021;18(11):6040. [PMID: 34199732]
  40. Spees LP, Brewster WR, Varia MA, Weinberger M, Baggett C, Zhou X, et al. Examining Urban and Rural differences in how Distance to Care Influences the initiation and completion of treatment among insured cervical Cancer PatientsUrban/Rural differences in treatment. Cancer Epidemiol Biomarkers Prev. 2019;28(5):882–9. [PMID: 30733307]
  41. Hjortsberg C. Why do the sick not utilise health care? The case of Zambia. Health Econ. 2003;12(9):755–70. [PMID: 12950094]
  42. Hjortsberg C, Mwikisa C. Cost of access to health services in Zambia. Health Policy Plann. 2002;17(1):71–7.
  43. Organization WH. Global atlas of Palliative Care 2nd Edition. London: Worldwide Palliative Care Alliance; 2020.
  44. Osman H, Shrestha S, Temin S, Ali ZV, Corvera RA, Ddungu HD, et al. Palliative care in the global setting: ASCO resource-stratified practice guideline. J Global Oncol. 2018;4:1–24.
  45. Krakauer EL, Kane K, Kwete X, Afshan G, Bazzett-Matabele L, Ruthnie Bien-Aimé DD, et al. Augmented Package of Palliative Care for Women with Cervical Cancer: responding to Refractory suffering. JCO Global Oncology. 2021;7:886–95. [PMID: 34115537]
  46. Kebebew T, Mavhandu-Mudzusi AH, Mosalo A. A cross-sectional assessment of symptom burden among patients with advanced cervical cancer. BMC Palliat Care. 2021;20:1–10.
  47. Downing J, Grant L, Leng M, Namukwaya E. Understanding models of palliative care delivery in sub-saharan Africa: learning from programs in Kenya and Malawi. J Pain Symptom Manag. 2015;50(3):362–70.
  48. Mwangi-Powell F. APCA’s role in the development of palliative care in Africa. Progress in Palliative Care. 2012;20(4):230–3.
  49. Stefan DC. Cancer care in Africa: an overview of resources. J Global Oncol. 2015;1(1):30–6.
  50. Brown CM, Richards KM, Vohra Y, Kanu C, Stevens L, Sasane R, et al. Evaluation of access to care issues in patients with breast cancer. J Med Econ. 2021;24(1):38–45. [PMID: 33317379]
  51. Brown CM, Kanu C, Richards KM, Stevens L, Sasane R, McAneny B. Exploring access to care from the perspective of patients with breast cancer: a qualitative study. Cancer Med. 2022.
  52. Stevenson DG. Growing pains for the Medicare hospice benefit. N Engl J Med. 2012;367(18):1683–5. [PMID: 23113479]
  53. Krakauer EL, Kwete X, Verguet S, Arreola-Ornelas H, Bhadelia A, Mendez O et al. Palliative care and pain control. Disease Control Priorities: Improving Health and Reducing Poverty 3rd edition. 2017.
  54. Stats S. Statistical release P0318: General Household Survey 2018. Pretoria: ISIbalo House; 2020.
  55. Thummapol O, Park T, Barton S. Exploring health services accessibility by indigenous women in Asia and identifying actions to improve it: a scoping review. Ethn Health. 2020;25(7):940–59. [PMID: 29722555]
  56. Kumar P, Casarett D, Corcoran A, Desai K, Li Q, Chen J, et al. Utilization of supportive and palliative care services among oncology outpatients at one academic cancer center: determinants of use and barriers to access. J Palliat Med. 2012;15(8):923–30. [PMID: 22731514]
  57. Mwaka AD, Okello ES, Orach CG. Barriers to biomedical care and use of traditional medicines for treatment of cervical cancer: an exploratory qualitative study in northern Uganda. Eur J Cancer Care. 2015;24(4):503–13.
  58. Mwaka AD, Mangi SP, Okuku FM. Use of traditional and complementary medicines by cancer patients at a national cancer referral facility in a low-income country. Eur J Cancer Care. 2019;28(6).

MeSH Term

Humans
Female
Palliative Care
Uterine Cervical Neoplasms
Developing Countries
Quality of Life
Hospice and Palliative Care Nursing

Word Cloud

Created with Highcharts 10.0.0carepalliativecanceraccessadvancedcervicalpatientsuterinewomenmiddle-incomefamiliesdiseaseimprovelow-countriesaccessibilityavailabilityreviewavailablehealthcarefacilitiespoorAccessBACKGROUND:WomensuffercombinationmoderateseverephysicalpsychologicalsocialspiritualdistressdueneedqualitylifeApproximately85%liveWhetherknownOBJECTIVES:understandgeographicfinancialacceptabilityMETHODS:conductedSystematicfollowingPRISMAguidelinesCINAHLCochraneCentralRegisterControlledTrialsMEDLINEPsychINFOPubMedScopuscoreconcepts:EligiblearticlespublishedEnglishcontainedoriginaldataexperiencesand/orcaregiversincludingsymptomsmanagementdiscussedresourcescommunicationsatisfactionutilizationRESULTS:OveralllimitedlocatedcitiesfarruralareaslivedPervasivepovertycommonaffordabilitytravellingaccommodationsubsistenceexpensesMisconceptionsknowledgeculturalbeliefsattitudeshealthsysteminsufficienciesalsopresentedchallengesCONCLUSION:ConcertedeffortmadeHealtheducationaddressmisconceptionscognitivebarrierslimitamongurgentlyundertakenLMICscervixcountries:systematicCervicalLowPalliative

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