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Oncology research
2023;31 (6): 877-885.

Progress in research on tumor microenvironment-based spatial omics technologies.

Fangmei Xie, Naite Xi, Zeping Han, Wenfeng Luo, Jian Shen, Jinggeng Luo, Xingkui Tang, Ting Pang, Yubing Lv, Jiabing Liang, Liyin Liao, Haoyu Zhang, Yong Jiang, Yuguang Li, Jinhua He
Author Information
  1. Fangmei Xie: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  2. Naite Xi: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  3. Zeping Han: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  4. Wenfeng Luo: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  5. Jian Shen: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  6. Jinggeng Luo: Department of General Surgery, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  7. Xingkui Tang: Department of General Surgery, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  8. Ting Pang: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  9. Yubing Lv: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  10. Jiabing Liang: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  11. Liyin Liao: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  12. Haoyu Zhang: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  13. Yong Jiang: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
  14. Yuguang Li: Administrating Office, He Xian Memorial Hospital, Southern Medical University, Guangzhou, China.
  15. Jinhua He: Central Laboratory, Panyu Central Hospital of Guangzhou, Guangzhou, China.
PMID: 37744276 DOI: 10.32604/or.2023.029494

Abstract

Spatial omics technology integrates the concept of space into omics research and retains the spatial information of tissues or organs while obtaining molecular information. It is characterized by the ability to visualize changes in molecular information and yields intuitive and vivid visual results. Spatial omics technologies include spatial transcriptomics, spatial proteomics, spatial metabolomics, and other technologies, the most widely used of which are spatial transcriptomics and spatial proteomics. The tumor microenvironment refers to the surrounding microenvironment in which tumor cells exist, including the surrounding blood vessels, immune cells, fibroblasts, bone marrow-derived inflammatory cells, various signaling molecules, and extracellular matrix. A key issue in modern tumor biology is the application of spatial omics to the study of the tumor microenvironment, which can reveal problems that conventional research techniques cannot, potentially leading to the development of novel therapeutic agents for cancer. This paper summarizes the progress of research on spatial transcriptomics and spatial proteomics technologies for characterizing the tumor immune microenvironment.

Keywords

Spatial omics Spatial proteomics Spatial transcriptomics Tumor microenvironment

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MeSH Term

Humans
Tumor Microenvironment
Fibroblasts
Gene Expression Profiling
Technology
Journal Article Review

Word Cloud

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