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Sep 13, 2023;21 (9):

Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells.

Sultan Pulat, Da-Ae Kim, Prima F Hillman, Dong-Chan Oh, Hangun Kim, Sang-Jip Nam, William Fenical
Author Information
  1. Sultan Pulat: College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea. ORCID
  2. Da-Ae Kim: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
  3. Prima F Hillman: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
  4. Dong-Chan Oh: Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
  5. Hangun Kim: College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea. ORCID
  6. Sang-Jip Nam: Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. ORCID
  7. William Fenical: Center of Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093-0204, USA.
PMID: 37755102 DOI: 10.3390/md21090489

Abstract

A HPLC-UV guided fractionation of the culture broth of sp. CNQ-617 has led to the isolation of a new Quinazolinone derivative, actinoquinazolinone (), as well as two known compounds, 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one () and 7-methoxy-8-hydroxy cycloanthranilylproline (). The interpretation of 1D, 2D NMR, and MS spectroscopic data revealed the planar structure of . Furthermore, compound suppressed invasion ability by inhibiting epithelial-mesenchymal transition markers (EMT) in AGS cells at a concentration of 5 µM. In addition, compound decreased the expression of seventeen genes related to human cell motility and slightly suppressed the signal transducer and activator of the transcription 3 (STAT3) signal pathway in AGS cells. Together, these results demonstrate that is a potent inhibitor of Gastric Cancer cells.

Keywords

Streptomyces sp. actinoquinazolinone gastric cancer marine natural products motility quinazolinone

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