Miaomiao Li: College of Basic Medicine, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Jihong Zhang: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Qilian Qin: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Huan Zhang: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ORCID
Xuan Li: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Hongtuo Wang: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Qian Meng: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ORCID
exhibits more than 5 months of vegetative growth in hemocoel. The peculiar development process of has been elucidated through morphological observation and omics technology; however, little information has been reported regarding the changes that occur in the host . The RNA sequencing data showed that when blastospores were in the proliferative stage, the greatest change in the infected larval fat body was the selectively upregulated immune recognition and antimicrobial peptide genes. When blastospores were in the stationary stage, the immune pathways of reverted to normal levels, which coincides with the successful settlement of . Pathway enrichment analysis showed a higher expression of genes involved in energy metabolism pathway in this stage. Metabolomic analyses revealed a reduction of amino acids and lipids in hemolymph, but an upregulation of lipids in the fat body of the host larvae after infection. We present the first transcriptome integrated with the metabolome study of infected by . It will improve our understanding of the interaction mechanisms between the host and entomopathogenic fungi, and facilitate future functional studies of genes and pathways involved in these interactions.
