Bayesian Trend Filtering via Proximal Markov Chain Monte Carlo.

Qiang Heng, Hua Zhou, Eric C Chi
Author Information
  1. Qiang Heng: Department of Statistics, North Carolina State University.
  2. Hua Zhou: Departments of Biostatistics and Computational Medicine, UCLA.
  3. Eric C Chi: Department of Statistics, Rice University.

Abstract

Proximal Markov Chain Monte Carlo is a novel construct that lies at the intersection of Bayesian computation and convex optimization, which helped popularize the use of nondifferentiable priors in Bayesian statistics. Existing formulations of proximal MCMC, however, require hyperparameters and regularization parameters to be prespecified. In this work, we extend the paradigm of proximal MCMC through introducing a novel new class of nondifferentiable priors called epigraph priors. As a proof of concept, we place trend filtering, which was originally a nonparametric regression problem, in a parametric setting to provide a posterior median fit along with credible intervals as measures of uncertainty. The key idea is to replace the nonsmooth term in the posterior density with its Moreau-Yosida envelope, which enables the application of the gradient-based MCMC sampler Hamiltonian Monte Carlo. The proposed method identifies the appropriate amount of smoothing in a data-driven way, thereby automating regularization parameter selection. Compared with conventional proximal MCMC methods, our method is mostly tuning free, achieving simultaneous calibration of the mean, scale and regularization parameters in a fully Bayesian framework.

Keywords

References

  1. Biometrics. 2004 Jun;60(2):398-406 [PMID: 15180665]
  2. Scand Stat Theory Appl. 2008 Sep 1;35(3):385-399 [PMID: 19763283]
  3. Bayesian Anal. 2018 Mar;13(1):225-252 [PMID: 29755638]

Grants

  1. R01 GM135928/NIGMS NIH HHS
  2. R01 HG006139/NHGRI NIH HHS
  3. R25 HD108136/NICHD NIH HHS
  4. R35 GM141798/NIGMS NIH HHS

Word Cloud

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