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International journal of molecular sciences
Sep 22, 2023;24 (19):

Mitochondria and Oxidative Stress as a Link between Alzheimer's Disease and Diabetes Mellitus.

Ivan M Veselov, Daria V Vinogradova, Andrey V Maltsev, Pavel N Shevtsov, Elena A Spirkova, Sergey O Bachurin, Elena F Shevtsova
Author Information
  1. Ivan M Veselov: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia.
  2. Daria V Vinogradova: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia.
  3. Andrey V Maltsev: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia.
  4. Pavel N Shevtsov: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia.
  5. Elena A Spirkova: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia.
  6. Sergey O Bachurin: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia. ORCID
  7. Elena F Shevtsova: Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences (IPAC RAS), Chernogolovka 142432, Russia. ORCID
PMID: 37833898 DOI: 10.3390/ijms241914450

Abstract

This review is devoted to the problems of the common features linking metabolic disorders and type 2 diabetes with the development of Alzheimer's disease. The pathogenesis of Alzheimer's disease closely intersects with the mechanisms of type 2 diabetes development, and an important risk factor for both pathologies is aging. Common pathological mechanisms include both factors in the development of oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as impaired mitochondrial dysfunctions and increasing cell death. The currently available drugs for the treatment of type 2 diabetes and Alzheimer's disease have limited therapeutic efficacy. It is important to note that drugs used to treat Alzheimer's disease, in particular acetylcholinesterase inhibitors, show a positive therapeutic potential in the treatment of type 2 diabetes, while drugs used in the treatment of type 2 diabetes can also prevent a number of pathologies characteristic for Alzheimer's disease. A promising direction in the search for a strategy for the treatment of type 2 diabetes and Alzheimer's disease may be the creation of complex multi-target drugs that have neuroprotective potential and affect specific common targets for type 2 diabetes and Alzheimer's disease.

Keywords

amyloidosis diabetes mitochondria neurodegenerative disease neuroinflammation neuroprotection oxidative stress

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Grants

  1. 22-13-00228/Russian Science Foundation

MeSH Term

Humans
Alzheimer Disease
Diabetes Mellitus, Type 2
Acetylcholinesterase
Mitochondria
Oxidative Stress

Chemicals

Acetylcholinesterase
Journal Article Review
Article has an altmetric score of 10

Word Cloud

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