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The Journal of infectious diseases
10 18, 2023;228 (Suppl 6): S446-S459.

Filoviruses: Scientific Gaps and Prototype Pathogen Recommendation.

Lesley C Dupuy, Christina F Spiropoulou, Jonathan S Towner, Jessica R Spengler, Nancy J Sullivan, Joel M Montgomery
Author Information
  1. Lesley C Dupuy: Virology Branch, Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. ORCID
  2. Christina F Spiropoulou: Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  3. Jonathan S Towner: Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ORCID
  4. Jessica R Spengler: Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  5. Nancy J Sullivan: National Emerging Infectious Diseases Laboratories, Boston University, Boston, Massachusetts, USA.
  6. Joel M Montgomery: Viral Special Pathogens Branch, Division of High Consequence Pathogens and Pathology, National Center for Emerging Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
PMID: 37849404 DOI: 10.1093/infdis/jiad362

Abstract

Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg (MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates. Sporadic outbreaks of filovirus disease occur in sub-Saharan Africa with reported case fatality rates ranging from 25% to 90%. The high mortality and increasing frequency and magnitude of recent outbreaks along with the increased potential for spread from rural to urban areas highlight the importance of pandemic preparedness for these viruses. Despite their designation as high-priority pathogens, numerous scientific gaps exist in critical areas. In this review, these gaps and an assessment of potential prototype pathogen candidates are presented for this important virus family.

Keywords

Ebola virus Marburg virus Sudan virus filoviruses prototype pathogens scientific gaps

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MeSH Term

Animals
Humans
Filoviridae
Ebolavirus
Hemorrhagic Fever, Ebola
Marburgvirus
Disease Outbreaks
Review Journal Article
Article has an altmetric score of 5

Word Cloud

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