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Oct 18, 2023;11 (10):

Vaccination Recommendations in Solid Organ Transplant Adult Candidates and Recipients.

Mauro Viganò, Marta Beretta, Marta Lepore, Raffaele Abete, Simone Vasilij Benatti, Maria Vittoria Grassini, Stefania Camagni, Greta Chiodini, Simone Vargiu, Claudia Vittori, Marco Iachini, Amedeo Terzi, Flavia Neri, Domenico Pinelli, Valeria Casotti, Fabiano Di Marco, Piero Ruggenenti, Marco Rizzi, Michele Colledan, Stefano Fagiuoli
Author Information
  1. Mauro Viganò: Gastroenterology Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  2. Marta Beretta: Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  3. Marta Lepore: Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  4. Raffaele Abete: Cardiology Division, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  5. Simone Vasilij Benatti: Infectious Diseases Unit, ASST Papa Giovanni XXII, 24127 Bergamo, Italy.
  6. Maria Vittoria Grassini: Gastroenterology Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  7. Stefania Camagni: Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy. ORCID
  8. Greta Chiodini: Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  9. Simone Vargiu: Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  10. Claudia Vittori: Cardiology Division, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  11. Marco Iachini: Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  12. Amedeo Terzi: Cardiothoracic Department, ASST Papa Giovanni XXII, 24127 Bergamo, Italy.
  13. Flavia Neri: Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  14. Domenico Pinelli: Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  15. Valeria Casotti: Pediatric Hepatology, Gastroenterology and Transplantation Unit, ASST Papa Giovanni XXII, 24127 Bergamo, Italy.
  16. Fabiano Di Marco: Pulmonary Medicine Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy. ORCID
  17. Piero Ruggenenti: Unit of Nephrology and Dialysis, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  18. Marco Rizzi: Infectious Diseases Unit, ASST Papa Giovanni XXII, 24127 Bergamo, Italy. ORCID
  19. Michele Colledan: Department of Organ Failure and Transplantation, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
  20. Stefano Fagiuoli: Gastroenterology Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, 24127 Bergamo, Italy.
PMID: 37897013 DOI: 10.3390/vaccines11101611

Abstract

Prevention of infections is crucial in solid organ transplant (SOT) candidates and recipients. These patients are exposed to an increased infectious risk due to previous organ insufficiency and to pharmacologic immunosuppression. Besides infectious-related morbidity and mortality, this vulnerable group of patients is also exposed to the risk of acute decompensation and organ rejection or failure in the pre- and post-transplant period, respectively, since antimicrobial treatments are less effective than in the immunocompetent patients. Vaccination represents a major preventive measure against specific infectious risks in this population but as responses to vaccines are reduced, especially in the early post-transplant period or after treatment for rejection, an optimal vaccination status should be obtained prior to transplantation whenever possible. This review reports the currently available data on the indications and protocols of vaccination in SOT adult candidates and recipients.

Keywords

chronic diseases heart infections kidney liver lungs prevention solid organ transplantation vaccination

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