The relationship between mood disorders, personality disorder and suicidality in adolescence: does general personality disturbance play a significant role in predicting suicidal behavior?

Riccardo Williams, Marco Chiesa, Marta Moselli, Camillla Frattini, MariaPia Casini, Peter Fonagy
Author Information
  1. Riccardo Williams: Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, "Sapienza" - University of Rome, Rome, Italy. riccardo.williams@uniroma1.it.
  2. Marco Chiesa: Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.
  3. Marta Moselli: Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, "Sapienza" - University of Rome, Rome, Italy.
  4. Camillla Frattini: Department of Dynamic and Clinical Psychology and Health Studies, Faculty of Medicine and Psychology, "Sapienza" - University of Rome, Rome, Italy.
  5. MariaPia Casini: Section of Child and Adolescent Neuro-Psychiatry, "Sapienza" - University of Rome, Rome, Italy.
  6. Peter Fonagy: Research Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Abstract

INTRODUCTION: Current research points to the importance personality pathology and major depression e as relevant psycopathological risk factors for understanding suicidal risk in adolescence. Literature has mainly focused on the role of BPD, however current orientations in personality pathological functioning suggest that BPD may be the representative of a general personality disturbance, a factor of vulnerability underlying diverse psychopathological variants and aspects of maladaptive functioning. However, recent studies seem to have neglected the contributions that other specific personality disorders and personality pathology as a general factor of vulnerability for suicidality; and only marginally investigated the interaction of personality disorder (PD) as an overall diagnosis and individual PDs and major depression (MDD). In this paper, the independent and cumulative effects of MDD and DSM-IV PDs on suicidal risk are investigated in a sample of adolescents observed in a longitudinal window of observation ranging from three months preceding the assessment to a six-month follow up period of clinical monitoring.
METHODS: A sample of 118 adolescents (mean age = 15.48 ± 1.14) referred for assessment and treatment on account of suicidal ideation or behavior were administered the CSSRS, SCID II, Kiddie-SADS at admission at inpatient and outpatient Units. All subjects included in the study had reported suicidal ideation or suicide attempts at the C-SSRS; The CSSRS was applied again to all patients who reported further suicidal episodes during the six-months follow-up period of clinical monitoring. Dimensional diagnoses of PDs was obtained by summing the number of criteria met by each subject at SCID-%-PD 5, In order, to test the significance of the associations between the variables chosen as predictors (categorical and dimensional PDs and MD diagnosis), and the suicidal outcomes variables suicide attempts, number of suicide attempts and potential lethality of suicide attempt, non-parametric bivariate correlations, logistic regression models and mixed-effects Poisson regression were performed PD.
RESULTS: The categorical and dimensional diagnosis of PD showed to be a significant risk factors for suicide attempt and their recurrence, independently of BPD, that anyway was confirmed to be a specific significant risk factor for suicidal behaviors. Furthermore, PD assessed at a categorical and dimensional level and major depression exert an influence on suicidal behaviors and their lethality both as independent and cumulative risk factors.
LIMITATIONS: Besides incorporating dimensional thinking into our approach to assessing psychopathology, our study still relied on traditionally defined assessment of PD. Future studies should include AMPD-defined personality pathology in adolescence to truly represent dimensional thinking.
CONCLUSION: These results point to the importance of early identification of the level of severity of personality pathology at large and its co-occurrence with major depression for the management of suicidal risk in adolescence.

Keywords

References

  1. Suicide Life Threat Behav. 2019 Apr;49(2):572-585 [PMID: 29577366]
  2. J Clin Psychiatry. 2009 Nov;70(11):1583-7 [PMID: 19607766]
  3. J Am Psychoanal Assoc. 2022 Feb;70(1):103-137 [PMID: 35451317]
  4. Lancet. 2011 May 28;377(9780):1814-5 [PMID: 21353696]
  5. World Psychiatry. 2017 Jun;16(2):215-216 [PMID: 28498598]
  6. Clin Psychol Rev. 2008 Jul;28(6):969-81 [PMID: 18358579]
  7. Am J Psychiatry. 2018 Sep 1;175(9):831-844 [PMID: 29621902]
  8. Psychopharmacol Bull. 2007;40(4):99-115 [PMID: 18227781]
  9. J Nerv Ment Dis. 1993 Mar;181(3):145-7 [PMID: 8445372]
  10. Am J Psychiatry. 2003 May;160(5):952-66 [PMID: 12727701]
  11. Front Psychiatry. 2021 Jan 13;11:598866 [PMID: 33519549]
  12. J Dual Diagn. 2019 Jul-Sep;15(3):159-171 [PMID: 31088228]
  13. Int J Environ Res Public Health. 2021 Sep 27;18(19): [PMID: 34639429]
  14. Am J Psychiatry. 2011 Dec;168(12):1266-77 [PMID: 22193671]
  15. Arch Suicide Res. 2014;18(4):295-312 [PMID: 24568371]
  16. J Pers Disord. 2010 Dec;24(6):773-84 [PMID: 21158599]
  17. Personal Ment Health. 2022 May;16(2):111-119 [PMID: 35362264]
  18. J Abnorm Psychol. 2016 Nov;125(8):1120-1134 [PMID: 27819472]
  19. Suicide Life Threat Behav. 2004 Summer;34(2):126-37 [PMID: 15191269]
  20. Psychopathology. 2020;53(3-4):198-204 [PMID: 32464626]
  21. J Pers Disord. 2017 Oct;31(5):577-589 [PMID: 28910213]
  22. Curr Opin Psychol. 2021 Feb;37:134-138 [PMID: 33513519]
  23. Bipolar Disord. 2014 Sep;16(6):652-61 [PMID: 24636453]
  24. Compr Psychiatry. 2016 Oct;70:141-51 [PMID: 27624434]
  25. BMC Psychiatry. 2021 Aug 9;21(1):393 [PMID: 34372810]
  26. Suicide Life Threat Behav. 2014 Feb;44(1):1-5 [PMID: 24313594]
  27. J Pers Disord. 2012 Dec;26(6):927-38 [PMID: 23281677]
  28. Suicide Life Threat Behav. 2006 Jun;36(3):313-22 [PMID: 16805659]
  29. J Clin Psychiatry. 2007 Feb;68(2):297-306 [PMID: 17335330]
  30. Am J Psychiatry. 2000 Apr;157(4):601-8 [PMID: 10739420]
  31. Psychol Assess. 2022 Dec;34(12):1112-1125 [PMID: 36107669]
  32. Epidemiol Psychiatr Sci. 2019 Nov 11;29:e68 [PMID: 31709966]
  33. J Affect Disord. 2016 Jun;197:231-8 [PMID: 26995466]
  34. Span J Psychol. 2018 Mar 26;21:E6 [PMID: 29576038]
  35. J Affect Disord. 2001 Mar;63(1-3):159-70 [PMID: 11246092]
  36. J Abnorm Psychol. 2015 May;124(2):387-98 [PMID: 25730515]
  37. Curr Opin Psychol. 2021 Feb;37:145-151 [PMID: 33571731]
  38. Psychiatr Clin North Am. 2018 Dec;41(4):669-683 [PMID: 30447731]
  39. Crisis. 2015;36(6):387-9 [PMID: 26648225]
  40. J Pers Disord. 2011 Jun;25(3):305-20 [PMID: 21699393]
  41. Int J Public Health. 2019 Mar;64(2):265-283 [PMID: 30635683]
  42. Int J Environ Res Public Health. 2021 Sep 16;18(18): [PMID: 34574681]
  43. Compr Psychiatry. 2007 Mar-Apr;48(2):145-54 [PMID: 17292705]
  44. Am J Psychiatry. 2007 Oct;164(10):1521-9; quiz 1622 [PMID: 17898343]
  45. Personal Ment Health. 2018 Feb;12(1):82-86 [PMID: 29226598]
  46. J Child Psychol Psychiatry. 2018 Apr;59(4):460-482 [PMID: 29090457]
  47. Psychiatr Clin North Am. 2018 Dec;41(4):583-593 [PMID: 30447726]
  48. Eur Child Adolesc Psychiatry. 2015 Nov;24(11):1307-20 [PMID: 26271454]
  49. J Am Acad Child Adolesc Psychiatry. 2014 May;53(5):528-49 [PMID: 24745953]
  50. J Can Acad Child Adolesc Psychiatry. 2008 Nov;17(4):197-201 [PMID: 19018322]
  51. Can J Psychiatry. 2015 Feb;60(2 Suppl 1):S46-54 [PMID: 25886671]
  52. Eur Child Adolesc Psychiatry. 2015 Apr;24(4):397-406 [PMID: 25084977]
  53. Personal Ment Health. 2017 Aug;11(3):157-163 [PMID: 28544496]
  54. J Child Psychol Psychiatry. 2015 Dec;56(12):1266-88 [PMID: 26251037]
  55. Personal Ment Health. 2013 May;7(2):89-101 [PMID: 24343935]
  56. Psychol Med. 2022 Jul;52(10):1838-1846 [PMID: 33028440]
  57. J Pers Disord. 2020 Dec;34(Supplement C):1-4 [PMID: 30802176]
  58. Bull Menninger Clin. 2011 Sep;75(3):236-53 [PMID: 21958318]
  59. J Am Acad Child Adolesc Psychiatry. 2017 Oct;56(10):825-831.e3 [PMID: 28942804]
  60. J Am Acad Child Adolesc Psychiatry. 2020 Oct;59(10):1130-1132 [PMID: 31654694]
  61. Child Psychiatry Hum Dev. 2000 Winter;31(2):99-111 [PMID: 11089299]
  62. Front Psychiatry. 2018 Oct 30;9:540 [PMID: 30425663]
  63. Personal Disord. 2021 Jan;12(1):86-92 [PMID: 32584090]
  64. Psychiatry Clin Neurosci. 2011 Apr;65(3):239-45 [PMID: 21507130]
  65. Child Psychiatry Hum Dev. 2023 Apr;54(2):290-311 [PMID: 34524583]
  66. Crisis. 2011;32(6):295-8 [PMID: 21945841]
  67. J Trauma Stress. 2007 Oct;20(5):869-79 [PMID: 17955525]
  68. Br J Psychiatry. 2019 Jul 11;:1-6 [PMID: 31292010]
  69. BMC Psychiatry. 2020 Nov 4;20(1):525 [PMID: 33148207]
  70. Personal Disord. 2014 Jan;5(1):26-31 [PMID: 24128121]
  71. J Affect Disord. 2021 Feb 15;281:714-720 [PMID: 33234284]
  72. BMC Psychiatry. 2012 Nov 08;12:191 [PMID: 23137108]
  73. Curr Opin Psychiatry. 2006 Jan;19(1):95-101 [PMID: 16612187]
  74. Psychiatry Res. 2016 Dec 30;246:261-266 [PMID: 27728869]
  75. Psychiatry Res. 2002 May 15;110(1):87-90 [PMID: 12007597]
  76. J Pers Disord. 2020 Dec;34(Supplement C):124-131 [PMID: 30650000]
  77. Arch Gen Psychiatry. 2011 Aug;68(8):827-37 [PMID: 21464343]
  78. Suicide Life Threat Behav. 2001 Winter;31(4):367-85 [PMID: 11775713]
  79. J Nerv Ment Dis. 2011 Oct;199(10):750-6 [PMID: 21964268]
  80. J Am Acad Child Adolesc Psychiatry. 1993 May;32(3):521-9 [PMID: 8496115]
  81. Eur Psychiatry. 2012 Oct;27(7):536-41 [PMID: 21696924]
  82. Am J Psychiatry. 2002 Dec;159(12):2042-7 [PMID: 12450954]
  83. Front Psychiatry. 2023 Mar 07;14:1098452 [PMID: 36960458]
  84. J Nerv Ment Dis. 2008 May;196(5):356-74 [PMID: 18477878]
  85. Annu Rev Clin Psychol. 2012;8:317-44 [PMID: 22458868]
  86. Mol Psychiatry. 2015 Jun;20(6):718-26 [PMID: 25980346]
  87. JAMA Pediatr. 2016 Apr;170(4):373-80 [PMID: 26832387]
  88. Psychiatr Clin North Am. 2018 Dec;41(4):575-582 [PMID: 30447725]
  89. Prog Neuropsychopharmacol Biol Psychiatry. 2008 May 15;32(4):1022-9 [PMID: 18313825]
  90. Brain Behav Immun Health. 2020 Aug;7:100124 [PMID: 32835300]
  91. JAMA Psychiatry. 2013 Mar;70(3):300-10 [PMID: 23303463]
  92. Psychiatry. 2008 Summer;71(2):169-82 [PMID: 18573036]

Word Cloud

Created with Highcharts 10.0.0personalitysuicidalriskPDsuicidedimensionalpathologyPDsMajorDepressionfactorsadolescenceBPDgeneralfactordisordersdisorderdiagnosisassessmentattemptscategoricalsignificantimportancerolefunctioningdisturbancevulnerabilitystudiesspecificsuicidalityinvestigatedMDDindependentcumulativesampleadolescentsperiodclinicalmonitoringideationCSSRSstudyreportednumbervariableslethalityattemptregressionbehaviorslevelthinkingPersonalityINTRODUCTION:CurrentresearchpointserelevantpsycopathologicalunderstandingLiteraturemainlyfocusedhowevercurrentorientationspathologicalsuggestmayrepresentativeunderlyingdiversepsychopathologicalvariantsaspectsmaladaptiveHoweverrecentseemneglectedcontributionsmarginallyinteractionoverallindividualmajordepressionpapereffectsDSM-IVobservedlongitudinalwindowobservationrangingthreemonthsprecedingsix-monthfollowMETHODS:118meanage = 1548 ± 114referredtreatmentaccountbehavioradministeredSCIDIIKiddie-SADSadmissioninpatientoutpatientUnitssubjectsincludedC-SSRSappliedpatientsepisodessix-monthsfollow-upDimensionaldiagnosesobtainedsummingcriteriametsubjectSCID-%-PD5ordertestsignificanceassociationschosenpredictorsMDoutcomespotentialnon-parametricbivariatecorrelationslogisticmodelsmixed-effectsPoissonperformedRESULTS:showedrecurrenceindependentlyanywayconfirmedFurthermoreassessedexertinfluenceLIMITATIONS:BesidesincorporatingapproachassessingpsychopathologystillreliedtraditionallydefinedFutureincludeAMPD-definedtrulyrepresentCONCLUSION:resultspointearlyidentificationseveritylargeco-occurrence withmanagementrelationshipmoodadolescence:playpredictingbehavior?AdolescenceMooddimensionsSuicide

Similar Articles

Cited By