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Molecular biotechnology
Nov, 2024;66 (11): 3013-3024.

Unlocking the Anticancer Potential of Frankincense Essential Oils (FEOs) Through Nanotechnology: A Review.

Rayya A Al-Balushi, Ashanul Haque, Mohd Saeed, Thuraya Al-Harthy, Mohammed Al-Hinaai, Salim Al-Hashmi
Author Information
  1. Rayya A Al-Balushi: Department of Basic and Applied Sciences, College of Applied and Health Sciences, A'Sharqiyah University, P.O. Box 42, Ibra, 400, Sultanate of Oman. rayya.albalushi@asu.edu.om. ORCID
  2. Ashanul Haque: Department of Chemistry, College of Science, University of Hail, Hail, Kingdom of Saudi Arabia. a.haque@uoh.edu.sa.
  3. Mohd Saeed: Department of Biology, College of Science, University of Hail, Hail, Kingdom of Saudi Arabia.
  4. Thuraya Al-Harthy: Department of Basic and Applied Sciences, College of Applied and Health Sciences, A'Sharqiyah University, P.O. Box 42, Ibra, 400, Sultanate of Oman.
  5. Mohammed Al-Hinaai: Department of Basic and Applied Sciences, College of Applied and Health Sciences, A'Sharqiyah University, P.O. Box 42, Ibra, 400, Sultanate of Oman.
  6. Salim Al-Hashmi: Department of Basic and Applied Sciences, College of Applied and Health Sciences, A'Sharqiyah University, P.O. Box 42, Ibra, 400, Sultanate of Oman.
PMID: 37914864 DOI: 10.1007/s12033-023-00918-5

Abstract

Cancer is a group of heterogeneous diseases that occur when cells in the body proliferate and divide uncontrollably. As the current treatment modalities have pros and cons, the discovery of new chemotherapeutic agents with the least side effects is one of the most investigated research areas. In this context, plant-based natural products are a rich source of drugs and have served humanity for ages. Frankincense essential oils (FEOs) are among the most promising plant-based oils in Gulf countries. In addition to their high cultural value, FEOs are also famous for their engaging biological activities, including anti-cancerous. However, the practical application of FEOs is often hindered/by their low water solubility, limited bioavailability, high volatility, and sensitivity toward heat, humidity, light, or oxygen. Thus, a significant demand for technological advancement would improve their ability to target particular cells and tissues. Nanotechnology emerged as an exciting approach in this context. Through suitable nano-formulation (functionalization or encapsulation into a nanostructure), issues arising due to solubility, targeting capability, and delivery can be controlled.

Keywords

Anticancer Breast cancer Essential oil Frankincense Melanoma Nanoformulations

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Grants

  1. MoHERI/BFP/RGP/HSS/20/105/Ministry of Higher Education, Research and Innovation

MeSH Term

Humans
Oils, Volatile
Nanotechnology
Frankincense
Animals
Neoplasms
Antineoplastic Agents, Phytogenic
Plant Oils
Antineoplastic Agents

Chemicals

Oils, Volatile
Frankincense
Antineoplastic Agents, Phytogenic
Plant Oils
Antineoplastic Agents
Journal Article Review
Article has an altmetric score of 1

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