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Molecular biology reports
Dec, 2023;50 (12): 10485-10507.

Advancements of fish-derived peptides for mucormycosis: a novel strategy to treat diabetic compilation.

Kadhirmathiyan Velumani, Abirami Arasu, Praveen Kumar Issac, Meenakshi Sundaram Kishore Kumar, Ajay Guru, Jesu Arockiaraj
Author Information
  1. Kadhirmathiyan Velumani: Institute of Biotechnology, Department of Medical Biotechnology and Integrative Physiology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602 105, India.
  2. Abirami Arasu: Department of Microbiology, SRM Arts and Science College, Kattankulathur, Chennai, Tamil Nadu, 603 203, India.
  3. Praveen Kumar Issac: Institute of Biotechnology, Department of Medical Biotechnology and Integrative Physiology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602 105, India. praveenkumari.sse@saveetha.com.
  4. Meenakshi Sundaram Kishore Kumar: Biomedical Research Unit and Laboratory Animal Centre (BRULAC), Department of Anatomy, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, 600 077, India.
  5. Ajay Guru: Department of Cariology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. ajayguru.sdc@saveetha.com.
  6. Jesu Arockiaraj: Toxicology and Pharmacology Laboratory, Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District, Tamil Nadu, 603203, India. jesuaroa@srmist.edu.in.
PMID: 37917415 DOI: 10.1007/s11033-023-08882-8

Abstract

Mucormycosis, an extremely fatal fungal infection, is a major hurdle in the treatment of diabetes consequences. The increasing prevalence and restricted treatment choices urge the investigation of novel therapeutic techniques. Because of their effective antimicrobial characteristics and varied modes of action, fish-derived peptides have lately emerged as viable options in the fight against Mucormycosis. This review examines the potential further application of fish-derived peptides in diagnosing and managing Mucormycosis in relation to diabetic complications. First, we examine the pathophysiology of Mucormycosis and the difficulties in treating it in diabetics. We emphasize the critical need for alternative therapeutic methods for tackling the limitations of currently available antifungal medicines. The possibility of fish-derived peptides as an innovative approach to combat Mucormycosis is then investigated. These peptides, derived from several fish species, provide wide antimicrobial properties against a variety of diseases. They also have distinct modes of action, such as rupture of cell membranes, suppression of development, and modification of the host immunological response. Furthermore, we investigate the problems and prospects connected with the clinical application of fish-derived peptides. Ultimately, future advances in fish-derived peptides, offer interesting avenues for the management of Mucormycosis in the context of diabetic comorbidities. More research and clinical trials are needed to properly investigate these peptide's therapeutic potential and pave the way for their adoption into future antifungal therapies.

Keywords

Anti-microbial peptides Diabetics Fish Mucormycosis Treatment

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MeSH Term

Animals
Mucormycosis
Antifungal Agents
Diabetes Mellitus
Diabetes Complications

Chemicals

Antifungal Agents
Journal Article Review

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