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Oct 31, 2023;13 (46): 32335-32362.

Synthesis, characterization and anti-breast cancer potential of an incensole acetate nanoemulsion from essential oil; , , and study.

Iffat Nayila, Sumaira Sharif, Madeeha Shahzad Lodhi, Muhammad Fayyaz Ur Rehman, Farhana Aman
Author Information
  1. Iffat Nayila: Institute of Molecular Biology and Biotechnology, The University of Lahore Lahore Pakistan iffat.nayila5@gmail.com Sumaira.Sharif@imbb.uil.edu.pk. ORCID
  2. Sumaira Sharif: Institute of Molecular Biology and Biotechnology, The University of Lahore Lahore Pakistan iffat.nayila5@gmail.com Sumaira.Sharif@imbb.uil.edu.pk.
  3. Madeeha Shahzad Lodhi: Institute of Molecular Biology and Biotechnology, The University of Lahore Lahore Pakistan iffat.nayila5@gmail.com Sumaira.Sharif@imbb.uil.edu.pk.
  4. Muhammad Fayyaz Ur Rehman: Institute of Chemistry, University of Sargodha Sargodha Pakistan.
  5. Farhana Aman: Department of Chemistry, The University of Lahore Sargodha Campus Sargodha Pakistan.
PMID: 37928847 DOI: 10.1039/d3ra06335f

Abstract

The characteristics of phytocompounds and essential oils have undergone extensive research in the medical and pharmaceutical sectors due to their extensive usage. In spite of the fact that these molecules are widely used, terpenes, terpenoids, and their derivatives have not yet been well characterized. This study intends to evaluate the prospective activity of incensole acetate (IA), a compound identified and isolated from essential oil by GC/MS analysis and column chromatography, and to analyze the anticancer effect of an IA biosynthesized nanoemulsion against breast cancer. The activity of IA against breast cancer targets was observed by molecular docking, ADMET assessment and molecular dynamics simulations. The IA-mediated nanoformulation exhibited cytotoxicity against breast cancer cell lines at an effective concentration when analyzed by MTT and crystal violet assay. The increased interleukin serum indicators were significantly improved as a result of nanoemulsion treatment in a DMBA-induced rat model. In addition, the anticancer properties of IA biosynthesized nanoemulsion are supported due to their potential effects on biochemical parameters, oxidative stress markers, proinflammatory cytokines, and upon tumor growth profiling in cancer-induced rats.

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Journal Article
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