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Jan, 2024;69 (1): 56-65.

Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period.

Tianming Lai, Jiarong Li, Zhengang Zhou, Jingwen Rao, Yong Zhu, Liang Xia, Yupeng Lei, Xin Huang, Huajing Ke, Yao Wu, Pi Liu, Hao Zeng, Huifang Xiong, Lingyu Luo, Youxiang Chen, Wenhua He, Yin Zhu, Nonghua Lu
Author Information
  1. Tianming Lai: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  2. Jiarong Li: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  3. Zhengang Zhou: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  4. Jingwen Rao: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  5. Yong Zhu: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  6. Liang Xia: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  7. Yupeng Lei: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  8. Xin Huang: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  9. Huajing Ke: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  10. Yao Wu: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  11. Pi Liu: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  12. Hao Zeng: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  13. Huifang Xiong: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  14. Lingyu Luo: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  15. Youxiang Chen: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  16. Wenhua He: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China. hewenhua@ncu.edu.cn. ORCID
  17. Yin Zhu: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
  18. Nonghua Lu: Department of Gastroenterology, Digestive Disease Hospital, First Affiliated Hospital of Nanchang University, 17 Yong Wai Zheng Street, 330006, Nanchang, Jiangxi, People's Republic of China.
PMID: 37943383 DOI: 10.1007/s10620-023-08172-0

Abstract

BACKGROUND: The worldwide incidence of acute pancreatitis (AP) is increasing, but the dominant etiology of AP may vary by country. Mixed etiologies are involved in the increase in the number of AP patients.
AIMS: This study was to analyze the etiological changes and prognosis of AP patients and explore the prognosis of AP patients with mixed etiologies.
METHODS: Using a retrospective analysis method, AP patients hospitalized from January 2007 to December 2021 were selected from a pancreatic center in Nanchang, China. Trends in the main etiologies were analyzed, and the severity and prognosis of different etiologies were compared.
RESULTS: A total of 10,071 patients were included. Cholelithiasis (56.0%), hyperlipidemia (25.3%), and alcohol (6.5%) were the top three etiologies. The proportion of acute biliary pancreatitis (ABP) showed a decreasing trend, while the proportion of hypertriglyceridemic pancreatitis (HTGP) and alcoholic AP showed an increasing trend (all p < 0.001). The incidence of organ failure and necrotizing pancreatitis was higher in patients with HTGP than in those with AP induced by other etiologies (all p < 0.05). There was no statistically significant difference in mortality among patients with different etiologies. Patients with AP due to a mixed hypertriglyceridemia-alcoholic etiology had higher ICU admission rates and were more severe than those with AP induced by other mixed etiologies.
CONCLUSION: In the past 15 years, the proportion of ABP has trended downward, while those of HTGP and alcoholic AP have risen. Among patients with mixed etiologies, those with a mixed hypertriglyceridemia-alcoholic etiology had a worse prognosis.

Keywords

Acute pancreatitis Etiology Prognosis Severity Trend

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Grants

  1. (2011)872/The National Key Clinical Specialist Project
  2. 81860122/National Natural Science Foundation of China
  3. 20192BCBL23021/Jiangxi Province Outstanding Youth Talent Funding Program
  4. 20201ZDG02007/Jiangxi Clinical Research Center for Gastroenterology

MeSH Term

Humans
Retrospective Studies
Acute Disease
Hypertriglyceridemia
Pancreatitis, Alcoholic
Prognosis
Journal Article

Word Cloud

Created with Highcharts 10.0.0APetiologiespatientspancreatitismixedprognosisetiologyproportionHTGPincidenceacuteincreasingdifferentABPshowedtrendalcoholicp < 0higherinducedPatientshypertriglyceridemia-alcoholicPrognosisAcuteBACKGROUND:worldwidedominantmayvarycountryMixedinvolvedincreasenumberAIMS:studyanalyzeetiologicalchangesexploreMETHODS:UsingretrospectiveanalysismethodhospitalizedJanuary2007December2021selectedpancreaticcenterNanchangChinaTrendsmainanalyzedseveritycomparedRESULTS:total10071includedCholelithiasis560%hyperlipidemia253%alcohol65%topthreebiliarydecreasinghypertriglyceridemic001organfailurenecrotizing05statisticallysignificantdifferencemortalityamongdueICUadmissionratessevereCONCLUSION:past15 yearstrendeddownwardrisenAmongworseEtiologicalChangesHospitalizedPancreatitis15-YearPeriodEtiologySeverityTrend

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