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Molecular neurodegeneration
Nov 10, 2023;18 (1): 82.

Simple model systems reveal conserved mechanisms of Alzheimer's disease and related tauopathies.

Yuwei Jiang, Lesley T MacNeil
Author Information
  1. Yuwei Jiang: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.
  2. Lesley T MacNeil: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada. macneil@mcmaster.ca. ORCID
PMID: 37950311 DOI: 10.1186/s13024-023-00664-x

Abstract

The lack of effective therapies that slow the progression of Alzheimer's disease (AD) and related tauopathies highlights the need for a more comprehensive understanding of the fundamental cellular mechanisms underlying these diseases. Model organisms, including yeast, worms, and flies, provide simple systems with which to investigate the mechanisms of disease. The evolutionary conservation of cellular pathways regulating proteostasis and stress response in these organisms facilitates the study of genetic factors that contribute to, or protect against, neurodegeneration. Here, we review genetic modifiers of neurodegeneration and related cellular pathways identified in the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, and the fruit fly Drosophila melanogaster, focusing on models of AD and related tauopathies. We further address the potential of simple model systems to better understand the fundamental mechanisms that lead to AD and other neurodegenerative disorders.

Keywords

Aggregation Alzheimer’s disease Amyloid-β C. elegans Cellular pathways Drosophila Genetic modifiers Neurodegeneration S. cerevisiae Tau Tauopathy

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Grants

  1. 390530/CIHR

MeSH Term

Animals
Alzheimer Disease
tau Proteins
Drosophila melanogaster
Disease Models, Animal
Tauopathies
Caenorhabditis elegans
Drosophila

Chemicals

tau Proteins
Journal Article Review
Article has an altmetric score of 13

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