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Lipids in health and disease
Nov 14, 2023;22 (1): 195.

Genetically predicted triglycerides mediate the relationship between type 2 diabetes Mellitus and intervertebral disc degeneration.

Ding-Qiang Chen, Wen-Bin Xu, Xin Chen, Ke-Yi Xiao, Zhi-Qiang Que, Nai-Kun Sun, Jin-Yi Feng, Gang Rui
Author Information
  1. Ding-Qiang Chen: The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
  2. Wen-Bin Xu: Department of Orthopedics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  3. Xin Chen: Department of Cardiac Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  4. Ke-Yi Xiao: The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
  5. Zhi-Qiang Que: Department of Orthopedics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  6. Nai-Kun Sun: Department of Orthopedics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
  7. Jin-Yi Feng: The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
  8. Gang Rui: The School of Clinical Medicine, Fujian Medical University, Fuzhou, China. reigang@163.com.
PMID: 37964277 DOI: 10.1186/s12944-023-01963-4

Abstract

BACKGROUND: To validate the causal relationship between type 2 diabetes Mellitus (T2DM) and intervertebral disc degeneration (IVDD) and to identify and quantify the role of triglycerides (TGs) as potential mediators.
METHODS: A two-sample Mendelian randomization (MR) analyses of T2DM (61,714 cases and 1178 controls) and IVDD (20,001 cases and 164,682 controls) was performed using genome-wide association studies (GWAS). Moreover, two-step MR was employed to quantify the proportionate impact of TG-mediated T2DM on IVDD.
RESULTS: MR analysis showed that T2DM increased IVDD risk (OR: 1.0466, 95% CI 1.0049-1.0899, P = 0.0278). Reverse MR analyses demonstrated that IVDD does not affect T2DM risk (P = 0.1393). The proportion of T2DM mediated through TG was 11.4% (95% CI 5.5%-17.4%).
CONCLUSION: This work further validates the causality between T2DM and IVDD, with a part of the effect mediated by TG, but the greatest impacts of T2DM on IVDD remain unknown. Further studies are needed to identify other potential mediators.

Keywords

Causality Intervertebral disc degeneration Mendelian randomization analyses Triglycerides Type 2 Diabetes Mellitus

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Grants

  1. No. 2020J011244/Natural Science Foundation of Fujian Province

MeSH Term

Humans
Diabetes Mellitus, Type 2
Genome-Wide Association Study
Intervertebral Disc Degeneration
Mendelian Randomization Analysis
Triglycerides

Chemicals

Triglycerides
Journal Article

Word Cloud

Created with Highcharts 10.0.0T2DMIVDDMR2discdegenerationanalysesrelationshiptypediabetesintervertebralidentifyquantifytriglyceridespotentialmediatorsMendelianrandomizationcasescontrolsstudiesrisk195%CIP = 0mediatedTG4%MellitusBACKGROUND:validatecausalmellitusroleTGsMETHODS:two-sample61714117820001164682performedusinggenome-wideassociationGWASMoreovertwo-stepemployedproportionateimpactTG-mediatedRESULTS:analysisshowedincreasedOR:04660049-108990278Reversedemonstratedaffect1393proportion1155%-17CONCLUSION:workvalidatescausalityparteffectgreatestimpactsremainunknownneededGeneticallypredictedmediateCausalityIntervertebralTriglyceridesTypeDiabetes

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