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Journal of virology
Dec 21, 2023;97 (12): e0157423.

LORF9 of Marek's disease virus is involved in the early cytolytic replication of B lymphocytes and can act as a target for gene deletion vaccine development.

Xiaojing Zhu, Lele Wang, Lele Gong, Yunyun Zhai, Rui Wang, Jiaxin Jin, Wenlong Lu, Xuyang Zhao, Yifei Liao, Gaiping Zhang, Guoqing Zhuang, Aijun Sun
Author Information
  1. Xiaojing Zhu: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. ORCID
  2. Lele Wang: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  3. Lele Gong: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  4. Yunyun Zhai: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  5. Rui Wang: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  6. Jiaxin Jin: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  7. Wenlong Lu: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  8. Xuyang Zhao: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.
  9. Yifei Liao: Division of Infectious Disease, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  10. Gaiping Zhang: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. ORCID
  11. Guoqing Zhuang: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. ORCID
  12. Aijun Sun: College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, China. ORCID
PMID: 38014947 DOI: 10.1128/jvi.01574-23

Abstract

IMPORTANCE: Marek's disease virus (MDV) is a highly infectious and oncogenic virus that can induce severe T cell lymphomas in chickens. MDV encodes more than 100 genes, most of which have unknown functions. This work indicated that the gene is necessary for MDV early cytolytic replication in B lymphocytes. In addition, we have found that the deletion mutant has a comparative immunological protective effect with CVI988/Rispens vaccine strain against very virulent MDV challenge. This is a significant discovery that LORF9 can be exploited as a possible target for the development of an MDV gene deletion vaccine.

Keywords

LORF9 Marek’s disease Marek’s disease virus gene deletion pathogenesis

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Grants

  1. U21A20260/MOST | National Natural Science Foundation of China (NSFC)

MeSH Term

Animals
B-Lymphocytes
Chickens
Gene Deletion
Herpesvirus 2, Gallid
Marek Disease
Marek Disease Vaccines
Poultry Diseases
Virus Replication

Chemicals

Marek Disease Vaccines
Journal Article
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0MDVdiseasevirusgenedeletioncanvaccineLORF9Marek'searlycytolyticreplicationBlymphocytestargetdevelopmentMarek’sIMPORTANCE:highlyinfectiousoncogenicinducesevereTcelllymphomaschickensencodes100genesunknownfunctionsworkindicatednecessaryadditionfoundmutantcomparativeimmunologicalprotectiveeffectCVI988/Rispensstrainvirulentchallengesignificantdiscoveryexploitedpossibleinvolvedactpathogenesis

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