OpenLB
Open Library of Bioscience
Advanced Search
Molecules (Basel, Switzerland)
Nov 24, 2023;28 (23):

Local Clays from China as Alternative Hemostatic Agents.

Changjiao Gan, Hongjie Hu, Zhiyun Meng, Xiaoxia Zhu, Ruolan Gu, Zhuona Wu, Wenzhong Sun, Peng Han, Hongliang Wang, Guifang Dou, Hui Gan
Author Information
  1. Changjiao Gan: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China. ORCID
  2. Hongjie Hu: Zhengzhou Institute of Multipurpose Utilization of Mineral Resources, Zhengzhou 450006, China.
  3. Zhiyun Meng: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  4. Xiaoxia Zhu: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  5. Ruolan Gu: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  6. Zhuona Wu: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  7. Wenzhong Sun: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  8. Peng Han: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  9. Hongliang Wang: Zhengzhou Institute of Multipurpose Utilization of Mineral Resources, Zhengzhou 450006, China.
  10. Guifang Dou: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
  11. Hui Gan: Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
PMID: 38067486 DOI: 10.3390/molecules28237756

Abstract

In recent years, the coagulation properties of inorganic minerals such as kaolin and zeolite have been demonstrated. This study aimed to assess the hemostatic properties of three local clays from China: natural kaolin from Hainan, natural halloysite from Yunnan, and zeolite synthesized by our group. The physical and chemical properties, blood coagulation performance, and cell biocompatibility of the three materials were tested. The studied materials were characterized by using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), X-ray fluorescence spectroscopy (XRF), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). All three clays showed different morphologies and particle size, and exhibited negative potentials between pH 6 and 8. The TGA and DSC curves for kaolin and halloysite were highly similar. Kaolin showed the highest water absorption capacity (approximately 93.8% ± 0.8%). All three clays were noncytotoxic toward L929 mouse fibroblasts. Kaolin and halloysite showed blood coagulation effects similar to that exhibited by zeolite, indicating that kaolin and halloysite are promising alternative hemostatic materials.

Keywords

clay halloysite hemostatic agent kaolin zeolite

References

  1. Blood Adv. 2020 Apr 28;4(8):1737-1745 [PMID: 32339233]
  2. Biomater Sci. 2023 Nov 21;11(23):7469-7488 [PMID: 37873611]
  3. Materials (Basel). 2019 May 10;12(9): [PMID: 31083390]
  4. Nat Commun. 2021 Oct 11;12(1):5922 [PMID: 34635666]
  5. ACS Appl Mater Interfaces. 2019 Jul 10;11(27):23848-23857 [PMID: 31245992]
  6. Carbohydr Polym. 2017 Dec 1;177:135-143 [PMID: 28962752]
  7. Nat Commun. 2019 Apr 29;10(1):1932 [PMID: 31036816]
  8. Bioact Mater. 2022 Jun 14;20:355-367 [PMID: 35784635]
  9. Nat Mater. 2013 Aug;12(8):729-34 [PMID: 23832126]
  10. PLoS One. 2020 Jul 24;15(7):e0236645 [PMID: 32706824]
  11. Mater Today Bio. 2021 Dec 22;13:100191 [PMID: 35024597]
  12. Materials (Basel). 2023 Oct 17;16(20): [PMID: 37895713]
  13. Molecules. 2019 Aug 30;24(17): [PMID: 31480278]
  14. ACS Appl Mater Interfaces. 2018 Oct 10;10(40):33913-33922 [PMID: 30220194]
  15. Nat Rev Immunol. 2013 Jan;13(1):34-45 [PMID: 23222502]
  16. J Mater Chem B. 2020 Aug 26;8(33):7335-7351 [PMID: 32687134]
  17. Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:1255-68 [PMID: 26478429]
  18. Colloids Surf B Biointerfaces. 2014 May 1;117:398-405 [PMID: 24675278]
  19. Food Res Int. 2021 Dec;150(Pt A):110737 [PMID: 34865756]
  20. Mater Sci Eng C Mater Biol Appl. 2021 Jan;118:111365 [PMID: 33254984]
  21. Int J Pharm. 2017 Nov 25;533(1):34-48 [PMID: 28943206]
  22. Molecules. 2023 Oct 14;28(20): [PMID: 37894563]
  23. Arterioscler Thromb Vasc Biol. 2019 Mar;39(3):331-338 [PMID: 30700128]
  24. Phys Chem Chem Phys. 2015 May 7;17(17):11198-203 [PMID: 25827491]
  25. Heliyon. 2018 Jul 10;4(7):e00689 [PMID: 30014048]
  26. Int J Biol Macromol. 2016 Feb;83:19-29 [PMID: 26616450]
  27. Acta Pharmacol Sin. 2013 Mar;34(3):367-72 [PMID: 23334236]
  28. Biomech Model Mechanobiol. 2021 Jun;20(3):1013-1030 [PMID: 33782796]
  29. Expert Opin Drug Deliv. 2019 Nov;16(11):1169-1182 [PMID: 31486344]
  30. Adv Healthc Mater. 2023 Aug;12(21):e2300075 [PMID: 37097067]
  31. Nanoscale. 2020 Dec 8;12(46):23444-23460 [PMID: 33237090]
  32. ACS Appl Mater Interfaces. 2019 May 1;11(17):15447-15456 [PMID: 30977359]
  33. Adv Sci (Weinh). 2023 Sep;10(25):e2300672 [PMID: 37344357]
  34. Molecules. 2019 Apr 17;24(8): [PMID: 30999685]
  35. Angew Chem Int Ed Engl. 2023 Jun 19;62(25):e202304734 [PMID: 37118980]
  36. J Environ Sci (China). 2017 Jun;56:254-262 [PMID: 28571862]
  37. Langmuir. 2007 Oct 23;23(22):11233-8 [PMID: 17892311]
  38. Molecules. 2017 May 20;22(5): [PMID: 28531126]
  39. Chem Sci. 2022 Nov 30;14(1):29-53 [PMID: 36605747]
  40. Mikrochim Acta. 2018 Jul 25;185(8):389 [PMID: 30046919]
  41. Adv Healthc Mater. 2021 Nov;10(22):e2101515 [PMID: 34558227]
  42. Polymers (Basel). 2018 Aug 15;10(8): [PMID: 30960844]
  43. ACS Omega. 2019 Nov 08;4(21):19442-19451 [PMID: 31763568]
  44. Nanoscale Res Lett. 2014 Mar 17;9(1):124 [PMID: 24636423]
  45. Chemosphere. 2023 Feb;314:137707 [PMID: 36592829]
  46. Ecotoxicol Environ Saf. 2018 Jul 15;155:1-8 [PMID: 29486406]
  47. Medchemcomm. 2019 Jun 10;10(8):1457-1464 [PMID: 31534660]
  48. J Mater Chem B. 2016 Nov 28;4(44):7146-7154 [PMID: 32263652]
  49. Cardiovasc Diagn Ther. 2017 Dec;7(Suppl 3):S267-S275 [PMID: 29399530]

Grants

  1. NO.7202148, 2016ZX09J16103-001-001/Beijing Municipal Natural Science Foundation(NO.7202148),Chinese National Science and Technology Key Projects for the financial assistance (2016ZX09J16103-001-001)

MeSH Term

Animals
Mice
Clay
Kaolin
Zeolites
China
Hemostatics

Chemicals

Clay
Kaolin
Zeolites
Hemostatics
Journal Article

Word Cloud

Created with Highcharts 10.0.0kaolinhalloysitezeolitethreecoagulationpropertieshemostaticclaysmaterialsshowednaturalbloodscanningspectroscopyX-rayTGADSCexhibitedsimilarKaolin8%recentyearsinorganicmineralsdemonstratedstudyaimedassesslocalChina:HainanYunnansynthesizedgroupphysicalchemicalperformancecellbiocompatibilitytestedstudiedcharacterizedusingelectronmicroscopySEMFouriertransforminfraredFTIRdiffractionXRDfluorescenceXRFthermogravimetricanalysisdifferentialcalorimetrydifferentmorphologiesparticlesizenegativepotentialspH68curveshighlyhighestwaterabsorptioncapacityapproximately93±0noncytotoxictowardL929mousefibroblastseffectsindicatingpromisingalternativeLocalClaysChinaAlternativeHemostaticAgentsclayagent

Similar Articles

Cited By