Wang Guo, Yu-Xuan Li, Yi Zhang, Xue-Rui Lv, Sheng-Xue Wang, Shuang-Yuan Zhang, En-Si Wang, Xin-Jie Chen, Yun Li
Objective: To determine sex differences in the prevalence of depression and assess the risk factors for depression among adult patients with epilepsy from the Dali area of China.
Methods: We retrospectively analyzed the clinical data of adult patients with epilepsy who visited the First Affiliated Hospital of Dali University from January 2017 to January 2022. Patient Health Questionnaire-9 was used to assess depressive symptoms in patients with epilepsy. The risk factors of depression were analyzed by binary logistic regression among different sex in patients with epilepsy.
Results: There were significant sex differences in depression in patients with epilepsy ( 0.001), and females were 4.27 times more likely to suffer from depression than males (95% confidence interval: 3.70-4.92). The risk factors for depression among female patients with epilepsy included occupation ( 0.001), years with epilepsy ( 0.001), seizure frequency ( 0.001), seizure type ( 0.001), etiology ( 0.001), number of antiseizure medications used ( 0.001), antiseizure medications ( 0.001), and electroencephalogram findings ( 0.001). The risk factors for depression among male patients with epilepsy included age ( 0.001), ethnicity ( 0.001), occupation ( 0.001), years with epilepsy ( 0.001), seizure frequency ( 0.001), seizure type ( 0.001), etiology ( 0.001), number of antiseizure medications used ( < 0.001), antiseizure medications ( 0.001), and electroencephalogram findings ( 0.001).
Conclusion: Adult female patients with epilepsy had a higher risk of depression than adult male patients with epilepsy. There were sex differences in the risk factors associated with depression among patients with epilepsy.
