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Materials today. Bio
Dec, 2023;23 100881.

Sprayable TiC MXene hydrogel for wound healing and drug release system.

Hyeongtaek Park, Jeong-Uk Kim, Soojin Kim, Nathaniel S Hwang, Hwan D Kim
Author Information
  1. Hyeongtaek Park: Department of IT Convergence (BK21 FOUR), Korea National University of Transportation, Chungju, 27469, Republic of Korea.
  2. Jeong-Uk Kim: School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, Seoul, 08826, Republic of Korea.
  3. Soojin Kim: Department of IT Convergence (BK21 FOUR), Korea National University of Transportation, Chungju, 27469, Republic of Korea.
  4. Nathaniel S Hwang: School of Chemical and Biological Engineering, Institute of Chemical Process, Seoul National University, Seoul, 08826, Republic of Korea.
  5. Hwan D Kim: Department of IT Convergence (BK21 FOUR), Korea National University of Transportation, Chungju, 27469, Republic of Korea.
PMID: 38161511 DOI: 10.1016/j.mtbio.2023.100881

Abstract

Wound healing is a critical process that facilitates the body's recovery from injuries and helps prevent infections, thereby maintaining overall tissue and organ functionality. However, delayed wound healing owing to various factors can lead to bacterial infections and secondary complications. In this study, a ciprofloxacin (CIP)-loaded MXene/sodium alginate (SA) hydrogel was fabricated to inhibit bacterial infections and enhance wound healing. The hydrogel was formulated in a sprayable state by blending CIP-loaded MXene (CIP-MX) with SA. This hydrogel was found to exhibit excellent photothermal conversion capability and biocompatibility under near-infrared (NIR) irradiation. In addition, the hydrogel enabled controlled drug release based on NIR irradiation, ultimately enabling improved antibacterial activity. Based on the and experiments, the CIP-loaded MXene/SA hydrogel (CIP-MX@Gel) accelerated wound healing. Overall, the CIP-MX@Gel has excellent potential as an effective wound healing material.

Keywords

Antibacterial Drug delivery Sprayable hydrogel Ti3C2 MXene Wound healing

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