Phage Therapy in Korea: A Prescribers' Survey of Attitudes Amongst Korean Infectious Diseases Specialists Towards Phage Therapy.

Shinwon Lee, Stephanie Lynch, Ruby C Y Lin, Heejoon Myung, Jonathan R Iredell
Author Information
  1. Shinwon Lee: Department of Internal Medicine, Pusan National University School of Medicine and Medical Research Institute, Pusan National University Hospital, Busan, Korea. ORCID
  2. Stephanie Lynch: Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW, Australia. ORCID
  3. Ruby C Y Lin: Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW, Australia. ORCID
  4. Heejoon Myung: Bioscience and Biotechnology, Hankuk University of Foreign Studies, Seoul, Korea. ORCID
  5. Jonathan R Iredell: Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, Westmead, NSW, Australia. ORCID

Abstract

BACKGROUND: Concerns about the rise in antimicrobial resistance have led to renewed interest in phage therapy worldwide, but perceptions among relevant medical professionals in Korea remain largely unknown.
MATERIALS AND METHODS: We conducted a semi-quantitative online survey to evaluate the Korean infectious disease specialists' perception of phage therapy.
RESULTS: We sent out the link to the questionnaire to 380 subjects and received 91 replies, with 90/91 respondents identifying as Korean Infectious Diseases specialists or trainees. Ten out of 91 (11.0%) respondents scored themselves as well-informed about phage therapy. The majority (93.4%) of respondents would consider using phage therapy if the safety of the phage formulation is guaranteed, and 80% of respondents would consider participating in clinical trials with phage therapy given adequate support. The biggest concern was uncertainty about safety (73.6%) and efficacy (65.9%). was ranked as a high priority for phage therapy research, as were bone and joint infections.
CONCLUSION: Korean Infectious Diseases specialists are receptive to phage therapy, but a better understanding of safety, efficacy and clinical trials are warranted to progress phage therapy within the Korean healthcare system.

Keywords

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Grants

  1. /PNU's Tenure-track Faculty

Word Cloud

Created with Highcharts 10.0.0phagetherapyKoreanrespondentsinfectioussafetyPhageresistance91diseasesspecialistsconsiderclinicaltrialsefficacyTherapyBACKGROUND:ConcernsriseantimicrobialledrenewedinterestworldwideperceptionsamongrelevantmedicalprofessionalsKorearemainlargelyunknownMATERIALSANDMETHODS:conductedsemi-quantitativeonlinesurveyevaluatediseasespecialists'perceptionRESULTS:sentlinkquestionnaire380subjectsreceivedreplies90/91identifyingtraineesTen110%scoredwell-informedmajority934%usingformulationguaranteed80%participatinggivenadequatesupportbiggestconcernuncertainty736%659%rankedhighpriorityresearchbonejointinfectionsCONCLUSION:receptivebetterunderstandingwarrantedprogresswithinhealthcaresystemKorea:Prescribers'SurveyAttitudesAmongstInfectiousDiseasesSpecialistsTowardsBacteriophagePerceptionAntimicrobial

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