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Apr, 2024;36 (16): e2313317.

Pillararene-Based Stimuli-Responsive Supramolecular Delivery Systems for Cancer Therapy.

Xin Li, Meili Shen, Jie Yang, Linlin Liu, Ying-Wei Yang
Author Information
  1. Xin Li: College of Chemistry and School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  2. Meili Shen: China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, P. R. China.
  3. Jie Yang: College of Chemistry and School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China.
  4. Linlin Liu: China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, P. R. China.
  5. Ying-Wei Yang: College of Chemistry and School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun, 130012, P. R. China. ORCID
PMID: 38206943 DOI: 10.1002/adma.202313317

Abstract

Cancer poses a significant challenge to global public health, seriously threatening human health and life. Although various therapeutic strategies, such as chemotherapy (CT), radiotherapy, phototherapy, and starvation therapy, are applied to cancer treatment, their limited therapeutic effect, severe side effects, and unsatisfactory drug release behavior need to be carefully considered. Thus, there is an urgent need to develop efficient drug delivery strategies for improving cancer treatment efficacy and realizing on-demand drug delivery. Notably, pillararenes, as an emerging class of supramolecular macrocycles, possess unique properties of highly tunable structures, superior host-guest chemistry, facile modification, and good biocompatibility, which are widely used in cancer therapy to achieve controllable drug release and reduce the toxic side effects on normal tissues under various internal/external stimuli conditions. This review summarizes the recent advance of stimuli-responsive supramolecular delivery systems (SDSs) based on pillararenes for tumor therapy from the perspectives of different assembly methods and hybrid materials, including molecular-scale SDSs, supramolecular nano self-assembly delivery systems, and nanohybrid SDSs. Moreover, the prospects and critical challenges of stimuli-responsive SDSs based on pillararenes for cancer therapy are also discussed.

Keywords

biomaterials cancer therapy drug delivery hybrid materials supramolecular chemistry

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Grants

  1. 52173200/National Natural Science Foundation of China
  2. 52203138/National Natural Science Foundation of China
  3. 20230101052JC/Natural Science Foundation of Jilin Province

MeSH Term

Humans
Drug Delivery Systems
Drug Liberation
Neoplasms
Journal Article Review
Article has an altmetric score of 1

Word Cloud

Created with Highcharts 10.0.0therapycancerdrugdeliverysupramolecularSDSspillararenesCancerhealthvarioustherapeuticstrategiestreatmentsideeffectsreleaseneedchemistrystimuli-responsivesystemsbasedhybridmaterialsposessignificantchallengeglobalpublicseriouslythreateninghumanlifeAlthoughchemotherapyCTradiotherapyphototherapystarvationappliedlimitedeffectsevereunsatisfactorybehaviorcarefullyconsideredThusurgentdevelopefficientimprovingefficacyrealizingon-demandNotablyemergingclassmacrocyclespossessuniquepropertieshighlytunablestructuressuperiorhost-guestfacilemodificationgoodbiocompatibilitywidelyusedachievecontrollablereducetoxicnormaltissuesinternal/externalstimuliconditionsreviewsummarizesrecentadvancetumorperspectivesdifferentassemblymethodsincludingmolecular-scalenanoself-assemblynanohybridMoreoverprospectscriticalchallengesalsodiscussedPillararene-BasedStimuli-ResponsiveSupramolecularDeliverySystemsTherapybiomaterials

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