Rudi Hendra, Monika Kerry Army, Neni Frimayanti, Hilwan Yuda Teruna, Rizky Abdulah, Ari Satia Nugraha
(Burm.f.) Bedd., a fern species native to India, Southeast Asia, Polynesia, and Australia, has a long history of medical including as a diabetic therapy. This study aimed to isolate bioactive compounds from ethyl acetate extract and assess their and inhibitory activities against -glucosidase and -amylase. The successful separation of five flavonols, namely stenopalustroside A (), tiliroside (), kaempferol (), quercetin (), and rutin (), was achieved through phytochemical analysis. The compounds exhibited a range of inhibitory activities against -glucosidase and -amylase, with IC values ranging from 40 to 250 µg/mL. Notably, the biological activities of compound have been reported for the first time. Compound was the most effective inhibitor of both enzymes among the isolated compounds. Studies performed reveal that the interactions between amino acids in compounds and are remarkably comparable to those observed in the positive control. These compounds share this commonality, and as a result, they both have the potential to be active agents.
