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02 27, 2024;24 (5): 996-1029.

Lipid vesicle-based molecular robots.

Zugui Peng, Shoji Iwabuchi, Kayano Izumi, Sotaro Takiguchi, Misa Yamaji, Shoko Fujita, Harune Suzuki, Fumika Kambara, Genki Fukasawa, Aileen Cooney, Lorenzo Di Michele, Yuval Elani, Tomoaki Matsuura, Ryuji Kawano
Author Information
  1. Zugui Peng: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  2. Shoji Iwabuchi: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  3. Kayano Izumi: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  4. Sotaro Takiguchi: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  5. Misa Yamaji: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  6. Shoko Fujita: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  7. Harune Suzuki: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  8. Fumika Kambara: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp.
  9. Genki Fukasawa: School of Life Science and Technology, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-Ku, Tokyo 152-8550, Japan.
  10. Aileen Cooney: Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, London W12 0BZ, UK.
  11. Lorenzo Di Michele: Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, UK. ORCID
  12. Yuval Elani: Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2AZ, UK. ORCID
  13. Tomoaki Matsuura: Earth-Life Science Institute, Tokyo Institute of Technology, Ookayama 2-12-1, Meguro-Ku, Tokyo 152-8550, Japan. ORCID
  14. Ryuji Kawano: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei-shi, Tokyo185-8588, Japan. rjkawano@cc.tuat.ac.jp. ORCID
PMID: 38239102 DOI: 10.1039/d3lc00860f

Abstract

A molecular robot, which is a system comprised of one or more molecular machines and computers, can execute sophisticated tasks in many fields that span from nanomedicine to green nanotechnology. The core parts of molecular robots are fairly consistent from system to system and always include (i) a body to encapsulate molecular machines, (ii) sensors to capture signals, (iii) computers to make decisions, and (iv) actuators to perform tasks. This review aims to provide an overview of approaches and considerations to develop molecular robots. We first introduce the basic technologies required for constructing the core parts of molecular robots, describe the recent progress towards achieving higher functionality, and subsequently discuss the current challenges and outlook. We also highlight the applications of molecular robots in sensing biomarkers, signal communications with living cells, and conversion of energy. Although molecular robots are still in their infancy, they will unquestionably initiate massive change in biomedical and environmental technology in the not too distant future.

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Grants

  1. MR/S031537/1/Medical Research Council
  2. /European Research Council

MeSH Term

Robotics
Nanotechnology
Technology
Lipids

Chemicals

Lipids
Journal Article Review Research Support, Non-U.S. Gov't
Article has an altmetric score of 32

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